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Mahesh M ★ India, 2015-09-15 10:03 (3935 d 19:23 ago) Posting: # 15397 Views: 4,486 |
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In draft guidance of Hydrocortisone mentioned “A 4 mg dose of dexamethasone should be administered 10 hours prior to drug administration as a pre-treatment to lower endogenous hydrocortisone levels.“ But in guidance not mentioned regarding base line correction or pre dose samples. Is it required to take pre dose samples for base line correction of hydrocortisone? Please share your thoughts on it. Thanks and regards Mahesh Edit: Subject line changed and guidance linked. [Helmut] |
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Mauricio Sampaio ★ Brazil, 2015-09-16 07:50 (3934 d 21:36 ago) @ Mahesh M Posting: # 15402 Views: 3,439 |
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❝ Is it required to take pre dose samples for base line correction of hydrocortisone? Dear Mahesh, the use of dexamethasone is decrease endogenous hydrocortisone levels. But the probability of minimum quantity exist! Therefore, the base line correction and pre dose samples are required. I hope this helps. |
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Mahesh M ★ India, 2015-09-16 08:50 (3934 d 20:37 ago) @ Mauricio Sampaio Posting: # 15403 Views: 3,440 |
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Hi Mauricio Sampaio, Thank you so much for your response Availability of literature, PAR and draft guidance not mentioned the same. So I am searching for some more clarity, do you have some references regarding the same. Thanks and regards |
Ing. Helmut Schütz