Bioequivalence and Bioavailability Forum • modified formulations

drrammohanj
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2007-12-08 13:09
(6780 d 04:57 ago)

Posting: # 1364
Views: 3,942

modified formulations [Regulatives / Guidelines]

Dear all,

Can you differentiate between Exteded Release (ER), Sustained Release (SR), Delayed Release (DR) formulations of Modified release (MR). How the PK characterstics modified release differ from Immediate Release formulations. Won't it not so that Drug in IR formulation following linear kinetics, will follow non-linear kinetics in MR form due release characterstics. Are there are any other differant MR forms

with
regards
Ram mohan

Gaurav Doshi
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2007-12-12 15:12
(6776 d 02:55 ago)

@ drrammohanj
Posting: # 1366
Views: 3,114

modified formulations

Post reply

Dear drrammohanj,

you have asked series of questions, let me try to answer your first one.

As per my Understanding; sustained release (SR) and extended release (ER) are synonymous which differs from delayed release.

SR or ER formulation dissolve slowly and release a drug over time so that they can be taken less frequently than instant release and that they keep steadier level of drug in the bloodstream. While delayed release formulation delays the release of medication to prevent it from getting destroyed or inactivated in gastric juices.

Thanks and regards,

Gaurav Doshi

drrammohanj ● 2007-12-14 06:56 (6774 d 11:10 ago) (edited on 2007-12-14 09:16) @ Gaurav Doshi Posting: # 1373 Views: 3,133	modified formulations Post reply
	Dear Gaurav Thanks for your kind reply. Can you differntiate between enteric coated tablet and delayed release tablet. with regards Ram Mohan -- Edit: Full quote removed. Please see this post! [Ohlbe]