Venkata Chaitanya Reddi
☆    

India,
2023-06-09 09:18
(714 d 18:10 ago)

Posting: # 23585
Views: 2,887
 

 Linagliptin/Metformin Hydrochloride film-coated tablets [Study As­sess­ment]

Hi All,

Greetings for the day!!!

Regarding Linagliptin/Metformin Hydrochloride film-coated tablets 2.5mg/1000mg Fed BE Study

Linagliptin Tmax is unexpectedly different and out of the range of 1-7 hours that the reference should be with 9 of 24 subjects having over 12 hours in Tmax.

any one can explain regarding what could be the reason for this.

Appreciate your time in advance.

Regards,
Venkata Chaitanya Reddi.


Edit: Category changed; see also this post #1[Helmut]

Venkata Chaitanya Reddi
dshah
★★  

India,
2023-06-09 13:51
(714 d 13:37 ago)

@ Venkata Chaitanya Reddi
Posting: # 23586
Views: 2,322
 

 Linagliptin/Metformin Hydrochloride film-coated tablets

Hello Venkata!

❝ Linagliptin Tmax is unexpectedly different and out of the range of 1-7 hours that the reference should be with 9 of 24 subjects having over 12 hours in Tmax.


❝ any one can explain regarding what could be the reason for this.

As per SBOA below Tmax range was observed!
[image]
I have not searched much, but even for Linagliptin alone formulation- higher Tmax can be seen.

Regards,
Divyen
Venkata Chaitanya Reddi
☆    

India,
2023-06-09 14:01
(714 d 13:28 ago)

@ dshah
Posting: # 23587
Views: 2,341
 

 Linagliptin/Metformin Hydrochloride film-coated tablets

Thank you Divyen!!! for your quick response.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Ohlbe]

Venkata Chaitanya Reddi
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