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saimsc007 ☆ India, 2012-06-29 12:58 (4692 d 01:18 ago) Posting: # 8868 Views: 7,685 |
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Dear All, Can Ctau be calculated from single dose pharmacokinetic parameters? Also what is the significance of Ctau with respect to single dose studies? thanks, Sai Kumar.K Edit: Category changed. [Helmut] |
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d_labes ★★★ Berlin, Germany, 2012-06-29 13:09 (4692 d 01:07 ago) @ saimsc007 Posting: # 8869 Views: 6,644 |
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Dear Sai Kumar.K ❝ Can Ctau be calculated from single dose pharmacokinetic parameters? What do you mean by using the acronym Ctau  .— Regards, Detlew |
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saimsc007 ☆ India, 2012-06-29 13:35 (4692 d 00:41 ago) @ d_labes Posting: # 8870 Views: 6,623 |
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❝ What do you mean by using the acronym Ctau Dear Detleff, Thanks for your response Ctau is a steady state parameter, but we want to calculate the same from single dose study. Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut] |
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Helmut ★★★   Vienna, Austria, 2012-06-29 15:54 (4691 d 22:21 ago) @ saimsc007 Posting: # 8872 Views: 7,335 |
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Hi Sai! ❝ Ctau is a steady state parameter, but we want to calculate the same from single dose study. If haven’t heard the term “Cτ” either. Do you have a reference? If you are able to get a reliable estimate of λz you may estimate Ĉmin at the intended dose interval. See this thread for a Phoenix/WinNonlin method and generally this presentation (together with a reference). — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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drgunasakaran1 ★★  2012-06-29 16:14 (4691 d 22:02 ago) @ saimsc007 Posting: # 8873 Views: 6,596 |
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Dear Mr Saimsc007, ❝ Can Ctau be calculated from single dose pharmacokinetic parameters? Concentration at the end of dosing interval, Ctau will usually calculated for Multiple dose studies. — Dr Gunasakaran Sambandan MD Disclaimer: The replies/posts are my personal opinions, and they do not represent my company's views on the same. LinkedIn |
Ing. Helmut Schütz