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ioanam ★ Romania, 2009-05-26 20:58 (5821 d 17:40 ago) Posting: # 3770 Views: 6,428 |
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Dear Members, there is any explanation to use Tmax to predict site of absorption of a drug? Because I don't consider that only this parameter offers me information regarding a gastric or intestinal absorption. Am I wrong? Thank you for your support, Ioanam Edit: Category changed. [Helmut] |
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Helmut ★★★   Vienna, Austria, 2009-06-04 16:30 (5812 d 22:08 ago) @ ioanam Posting: # 3823 Views: 5,573 |
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Dear Ioanam! ❝ there is any explanation to use Tmax to predict site of absorption of a drug? tmax is a rather primitive metric used only in NCA of BE. ❝ Because I don't consider that only this parameter offers me information regarding a gastric or intestinal absorption. Remember that tmax is not a model parameter in PK, but a derived one - depending on both absorption, distribution, elimination, etc. Imagine a gastric-resistant formulation of the weak acid diclofenac. There's no absorption window for this drug - it will be absorbed in the entire gut. If you see tmax in one subject at 1 h and in another at 16 h, the absorption site most likely is just the same! — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz