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Ramc ☆ 2010-10-07 08:16 (5335 d 00:59 ago) Posting: # 6012 Views: 4,954 |
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Hi, In reference replicated study (TRR), is it mandatory to have the data of all 3 periods completed for stat analysis? Should 1 test + 1 R also be included in the stat with out any regulatory constraints? Please suggest Edit: Category changed. [Helmut] |
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d_labes ★★★ Berlin, Germany, 2010-10-07 10:26 (5334 d 22:49 ago) @ Ramc Posting: # 6013 Views: 4,021 |
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Dear Ramc, ❝ In reference replicated study (TRR), is it mandatory to have the data of all 3 periods completed for stat analysis? Yes. BTW: The sequences in a reference replicate 3-period study are TRR/RTR/RRT. ❝ Should 1 test + 1 R also be included in the stat with out any regulatory constraints? No. Why would you discard part of your data? A further hint: Search the forum for some rather long discussions about that topic. — Regards, Detlew |
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Ramc ☆ 2010-10-07 10:47 (5334 d 22:28 ago) @ d_labes Posting: # 6015 Views: 4,036 |
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Thanks Labes. My concern is there are few subjects who completed only two periods with 1T and 1R. I understood from your response that these subjects should be excluded from the analysis. am i correct? Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe] |
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Ohlbe ★★★ France, 2010-10-07 12:39 (5334 d 20:36 ago) @ Ramc Posting: # 6016 Views: 3,983 |
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Dear Ramc, ❝ I understood from your response that these subjects should be excluded from the analysis. am i correct? You are not. You need to consider all subjects for which you have data from the test and at least one period for the reference. Regards Ohlbe — Regards Ohlbe |
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ElMaestro ★★★ Denmark, 2010-10-07 12:59 (5334 d 20:16 ago) @ Ramc Posting: # 6017 Views: 4,043 |
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Hi Ramc, I think Ohlbe is correct here. With a semi-replicated design you will typically be using a mixed model; this allows for inclusion of all data, and if some of the vols have a period missing for Ref then that's not going to be an issue as long as missing periods are missing at random. — Pass or fail! ElMaestro |
Ing. Helmut Schütz