Bioequivalence and Bioavailability Forum • 90% CI of ratio of SDs for NTI drugs

Satish
☆

India,
2015-07-15 10:35
(3590 d 09:17 ago)

Posting: # 15083
Views: 5,150

90% CI of ratio of SDs for NTI drugs [RSABE / ABEL]

Dear all,

As we know for NTI drugs guidelines Warfarin has suggested that use both (1) scaled and unscaled ABE, in addition to that (2) calculation of 90% CI of ratio of within subject standard deviation of test to reference product.

here my problem is (2). i don't know how to calculate (2). but i tried it with 'COVPRMS' of 'PROC MIXED' from normal ln transformed data (not from ilat, dlat). i calculated within subject standard deviation for test and reference using 'estimates' in 'COVPRMS'. now i just want to know am i doing it in the correct way or not?

Thanks and Regards,
Satish.

khaledazeid ☆ 2016-12-31 13:57 (3055 d 04:56 ago) @ Satish Posting: # 16919 Views: 2,999	90% CI of ratio of SDs for NTI drugs Post reply
	Dear Satish I have the same problem as you, so i hope you found a solution for it. If so please tell me thanks in advance Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]