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Cmax ☆ India, 2010-08-13 20:12 (5384 d 05:13 ago) Posting: # 5782 Views: 7,309 |
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Hai Everyone, Is it possible to find out whether the drug follows linear or non linear kinetic from a single dose study ? thanks and regards Cmax |
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ElMaestro ★★★ Denmark, 2010-08-13 20:31 (5384 d 04:54 ago) @ Cmax Posting: # 5784 Views: 6,008 |
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Hi Cmax, if by "single dose study" you mean a single study in which one dose level has been applied then the answer is no. To investigate linearity several dose levels need to be investigated. — Pass or fail! ElMaestro |
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Helmut ★★★   Vienna, Austria, 2010-08-13 21:11 (5384 d 04:14 ago) @ ElMaestro Posting: # 5785 Views: 6,069 |
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Dear ElMestro & Cmax (interesting nick)! ❝ To investigate linearity several dose levels need to be investigated. ... and the design depends on how much previous information about the drug one has. Single dose studies generally suffice for most drugs, but for new drugs (i.e., full characterisation of pharmacokinetics) one has to opt for steady state. Otherwise time-dependent effects (e.g., enzyme-induction or -inhibition) may not be detected. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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Cmax ☆ India, 2010-08-27 22:04 (5370 d 03:22 ago) @ Helmut Posting: # 5861 Views: 5,875 |
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dear all, thanks and i rephrase my question here "if i have a BE study from that how we can make it out is it follows non linear kinetic... if you search in internet few works shows it follows non linear PK..."  |
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Helmut ★★★ Vienna, Austria, 2010-08-28 16:29 (5369 d 08:56 ago) @ Cmax Posting: # 5863 Views: 5,847 |
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Dear Cmax! ❝ if i have a BE study from that how we can make it out is it follows non linear kinetic... BE studies (test vs. reference at the same dose level) are not suitable to assess dose proportionality. I have occasionally seen 4-way cross-over studies (three dose levels of test vs. one dose level of reference). ❝ if you search in internet few works shows it follows non linear PK... So what? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz