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jag009 ★★★ NJ, 2019-08-22 16:53 (2087 d 15:42 ago) Posting: # 20506 Views: 5,242 |
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Hi, Does anyone know if it is possible to estimate the intrasubject CV of a drug for a fed study if only the food effect data is available (and fasting BE study data)? Thanks J |
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ElMaestro ★★★ Denmark, 2019-08-22 23:56 (2087 d 08:40 ago) @ jag009 Posting: # 20507 Views: 4,252 |
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Hi jag, ❝ Does anyone know if it is possible to estimate the intrasubject CV of a drug for a fed study if only the food effect data is available (and fasting BE study data)? It is not readily possible. Both a negative and a positive food effect can be accompanied by a decreased or increased CV. You'll need to work hard for this one  — Pass or fail! ElMaestro |
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zaibo liu ☆ China, 2019-08-23 04:54 (2087 d 03:42 ago) @ jag009 Posting: # 20508 Views: 4,209 |
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❝ Does anyone know if it is possible to estimate the intrasubject CV of a drug for a fed study if only the food effect data is available (and fasting BE study data)? It is not possible, but intrasubject CV is always small than fasting for BCS II or first pass drug. |
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jag009 ★★★ NJ, 2019-09-04 08:32 (2075 d 00:04 ago) @ zaibo liu Posting: # 20538 Views: 4,036 |
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Thanks guys, ❝ It is not possible, but intrasubject CV is always small than fasting for BCS II or first pass drug. You mean ISCV is smaller under fed (than fasting) for BCS II? Any example drug? Thanks John |
Ing. Helmut Schütz