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jag009 ★★★ NJ, 2014-01-21 00:25 (4127 d 19:57 ago) Posting: # 12211 Views: 8,013 |
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Hi everyone, Anyone has experience in modeling pk profile with enterohepatic recirculation? Literature references would be very helpful. Thanks John |
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luvblooms ★★ India, 2014-01-21 12:47 (4127 d 07:35 ago) @ jag009 Posting: # 12214 Views: 7,057 |
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Dear John ❝ Literature references would be very helpful. Try these ones
Regards — ~A happy Soul~ |
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Helmut ★★★   Vienna, Austria, 2014-01-21 14:00 (4127 d 06:22 ago) @ jag009 Posting: # 12215 Views: 6,963 |
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Hi John, Gabrielsson/Weiner (all editions) contains “PK40” in classical WinNonlin-code. I modified it a while ago for po dosing. In my experience the biggest obstacle was finding constraints for the gall bladder emptying time if the reabsorbed fraction was not pronounced. More an art than science. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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jag009 ★★★ NJ, 2014-01-21 17:18 (4127 d 03:04 ago) @ Helmut Posting: # 12216 Views: 6,971 |
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Thanks guys  |
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jag009 ★★★ NJ, 2014-01-23 17:18 (4125 d 03:04 ago) @ Helmut Posting: # 12245 Views: 6,921 |
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Hi Helmut, ❝ Gabrielsson/Weiner (all editions) contains “PK40” in classical WinNonlin-code. I modified it a while ago for po dosing. In my experience the biggest obstacle was finding constraints for the gall bladder emptying time if the reabsorbed fraction was not pronounced. More an art than science. Question... Have you tried using the graphic editor in Phoenix to do this? How do you factor in the bile emptying interval (or the "lagtime" before the bile is released into the gut and subsquently the reabsorption from the GI")? Thanks John |
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Helmut ★★★ Vienna, Austria, 2014-01-23 17:29 (4125 d 02:53 ago) @ jag009 Posting: # 12246 Views: 6,880 |
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Hi John, ❝ Have you tried using the graphic editor in Phoenix to do this? How do you factor in the bile emptying interval (or the "lagtime" before the bile is released into the gut and subsquently the reabsorption from the GI")? Nope. I only once translated a two-sequence absorption model (MPH  ) from my classical WNL-code to PHX. Took me days… I’m too busy right now to give you the details – I suggest to ask at Pharsight’s Extranet in the meantime. It would be useful if you could upload a project containing data of one profile.— Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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jag009 ★★★ NJ, 2014-01-23 21:09 (4124 d 23:13 ago) @ Helmut Posting: # 12251 Views: 6,892 |
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❝ Nope. I only once translated a two-sequence absorption model (MPH I made a model for biphasic (or mixture) release as well for a drug but this enterohepatic gets me beacause I don't know the amount from the biliary compartment to begin with (brain cramp for now). I will post something later for you to play with when you have time. Thanks John P.S. I am looking into PK40 now. Linda from Pharsight posted it for me after my message on Pharsight's forum. |
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SDavis ★★ UK, 2014-01-24 15:21 (4124 d 05:01 ago) @ Helmut Posting: # 12261 Views: 6,981 |
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Hi, In case anyone else is also looking for the Phoenix code to attempt modelling Enterohepatic Recirculation; here is the direct link to the suggested cross posting. Simon http://www.pharsight.com/extranet/index.php?option=com_kunena&Itemid=55&func=view&catid=45&id=2243#2244 (You will need to sign in to see the post, please contact me directly if you haven't received your Pharsight forum authentication email* within 6 hours and it's not in your Spam folder) * Assuming you don't mistype your own email address, I believe that error is about 1 in 15 currently  )— Simon Senior Scientific Trainer, Certara™ [link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link] https://www.certarauniversity.com/dashboard https://support.certara.com/forums/ |
Ing. Helmut Schütz