Dr_Dan
★★  

Germany,
2010-12-10 15:15
(5253 d 00:30 ago)

Posting: # 6289
Views: 5,393
 

 discrepancy in results ANOVA vs summary stats [🇷 for BE/BA]

Dear Yung-jin and all others
I just installed BEAR 2.5.3 and tried to get used to it by recalculating a BE study: 18 subjects included, 17 completed the study, so the data set is inbalanced. When I look at the results in the files Statistical_summaries.txt and ANOVA_stat.txt I realized that there is a discrepancy:

Statistical_summaries.txt:
    Parameters  F values  P vales    PE (%)  lower 90%CI  upper 90%CI
1         Cmax     1.000    0.333         -            -            -
2       AUC0-t     0.176    0.681         -            -            -
3     AUC0-inf     0.133    0.720         -            -            -
4     ln(Cmax)     0.617    0.444    97.329       91.635      103.376
5   ln(AUC0-t)     0.001    0.975   100.003       96.217      103.938
6 ln(AUC0-inf)     0.003    0.957   100.227       95.924      104.724


ANOVA_stat.txt:
Cmax        97.334       91.641      103.382
AUC0-t      99.930       96.146      103.862
AUC0-inf   100.136       95.837      104.629


The calculation was performed at the same time using the same data set. Could you please explain why? I would have expected that they should be exactly the same. What is the reason for presenting different point estimators and confidence intervals?
I am looking forward to your reply
Kind regards
Dan

Kind regards and have a nice day
Dr_Dan
yjlee168
★★★
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Homepage
Kaohsiung, Taiwan,
2010-12-10 20:51
(5252 d 18:54 ago)

(edited on 2010-12-10 23:39)
@ Dr_Dan
Posting: # 6291
Views: 4,319
 

 discrepancy in results ANOVA vs summary stats

Dear Dr. Dan,

I think that you just found a bug in bear with imbalanced dataset of a 2x2 crossover. It only happens to imbalanced dataset. The test dataset that I used was a balanced dataset. Thus, it has not been found or reported before. I will fix the bug soon. Sorry about this and thank you for your feedback.

---
[Edit]: I've already fixed the error now (I think) and will test it with more data later.

All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
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