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NPavan ☆ India, 2009-06-29 16:14 (6196 d 20:14 ago) Posting: # 3915 Views: 4,144 |
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Dear all, We conducted a study with 2 tests and 1 reference. According to our SOP if R2 value is less than 0.75 we need to exclude that subject from the statistical analysis of kel, t1/2 and AUCinf. In this 3x3 design for T2 the R2 value is showing less than 0.75. We are considering kel, t1/2 and AUCinf for T2 as missing. Now my doubt is... Is it applicable to T2 only or for T1 and R also we need to take them as missing? kindly suggest me. Thanks in advance. — Regards, Pavan |
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Helmut ★★★   Vienna, Austria, 2009-06-29 16:30 (6196 d 19:58 ago) @ NPavan Posting: # 3916 Views: 3,280 |
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Dear Pavan, ❝ We conducted a study with 2 tests and 1 reference. According to our SOP if R2 value is less than 0.75 we need to exclude that subject from the statistical analysis OK, if your SOP states this cut-off you have to use it. For the meaningfulness of R² as a measure of ‘goodness of fit’ please search the forum. We had rather lengthy discussions on the topic already. ❝ In this 3x3 design for T2 the R2 value is showing less than 0.75. We are considering kel, t1/2 and AUCinf for T2 as missing. What are your considerations? You have to follow your SOP. ❝ Is it applicable to T2 only […] IMHO yes. ❝ […] or for T1 and R also we need to take them as missing? Why? For these formulations R² ≥0.075. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz