graveendranath
☆    

2009-03-18 06:18
(6298 d 23:10 ago)

Posting: # 3376
Views: 6,625
 

 Level of Significance for Sequence effect [General Sta­tis­tics]

Dear sir,

For ANOVA calculation some articles showing 10% level of significane for testing sequence effect, 5% for Period and Treatment effects and some articles showing 5% for all sequence, period and treatment effects.
I have confusion which one is correct? Please suggest me the correct Level of Significance for Sequence.
sinhmar
☆    

India,
2009-03-21 12:31
(6295 d 16:58 ago)

@ graveendranath
Posting: # 3388
Views: 5,518
 

 Level of Significance for Sequence effect

❝ For ANOVA calculation some articles showing 10% level of significane for

❝ testing sequence effect, 5% for Period and Treatment effects and some

❝ articles showing 5% for all sequence, period and treatment effects.

❝ I have confusion which one is correct? Please suggest me the correct Level

❝ of Significance for Sequence.


Dear graveendranath,

Both are correct it's on our wish, how much stringent we want to be.
Generally, in BE studies as per regulatory requirement, to test the carryover effect in 2 way crossover design, the sequence effect is tested at the 10% level of significance using the subjects nested within sequence mean square as the error term. And all other main effects(treatment, period etc.) are tested at 5% level of significance against the residual error(MSE) from ANOVA model as error term.


Sinhmar
KR
★    

India,
2009-03-28 06:46
(6288 d 22:43 ago)

@ sinhmar
Posting: # 3407
Views: 5,477
 

 Level of Significance for Sequence effect

Dear Sinhmar,
If we use different significance level for difference effects then how can we do this using PROC MIXED or PROC GLM using sas?

Regards,
KR


Edit: Full quote removed. Please see this post. Helmut
sinhmar
☆    

India,
2009-03-30 13:53
(6286 d 16:36 ago)

@ KR
Posting: # 3414
Views: 5,400
 

 Level of Significance for Sequence effect

Dear KR

❝ If we use different significance level for difference effects then how can we do this using PROC MIXED or PROC GLM using sas?


Using PROC MIXED or PROC GLM in SAS we can calculate F value and P-value for different effects and we need level of significance to find tabulated F value which we can find from F-distribution tables.
To check that effect is significant or not, we see calculated F-value against tabulated F- value (at level of significance= 0.05 or 0.10 or...) or if we have SAS output we simply see level of significance against p-value of the effect.

Regards,
Sinhmar
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