atish_azad
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2008-09-30 11:50
(6468 d 00:31 ago)

Posting: # 2443
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 Replicated Bioequivalence Study [General Sta­tis­tics]

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Dear HS and all,

For Balanced data:
1. I have done manual calculation for two period crossover study and even matched my answer to the output given by WinNonlin and SAS software. But in case of replicated study I failed to do so.
2. After extensive reading I realized that variance should be calculated using REML = restricted maximum likelihood.
Kindly guide me for manual calculation for a replicated study.

Regards,

Atish

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Edit: Category changed. [Jaime]
 
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