Bioequivalence and Bioavailability Forum

Laszlo Istvan Orosz
☆

Hungary,
2021-06-09 16:12
(1820 d 21:05 ago)

Posting: # 22395
Views: 6,972

DDSolver Issue [General Statistics]

Dear All,

i can't reproduce the variance-covariance matrix in modell depended approaches results.
Based on the math, it would be easy to calculate, but i can't reproduce with excel data analysis and with my linear algebr knowledge.

The variance-covariance matrix is essential, to calculate the mahalonobis distance, what show the similarity.

How does calculate DDSolver the variance-covariance matrix?

If you need, i can send you my calculations in mail.

Helmut ★★★ Vienna, Austria, 2021-06-09 17:29 (1820 d 19:47 ago) @ Laszlo Istvan Orosz Posting: # 22396 Views: 5,724	DDSolver Issue Post reply
	Hi László, see this thread. I recommend `bootf2BCA v1.2` for (see there). ❝ How does calculate DDSolver the variance-covariance matrix? Sorry, no idea. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes

Laszlo Istvan Orosz ☆ Hungary, 2021-06-09 17:33 (1820 d 19:44 ago) @ Helmut Posting: # 22397 Views: 5,680	DDSolver Issue Post reply
	Thank You Helmut! Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Helmut
★★★

Vienna, Austria,
2021-06-09 23:33
(1820 d 13:43 ago)

@ Laszlo Istvan Orosz
Posting: # 22400
Views: 5,746

DDSolver Issue

Post reply

Hi László,

❝ Thank You Helmut!

Welcome. Aleksander Mendyk published bootf2BCA v1.3 on 2021-05-08.

Lines 394–405 of F2_boot.R are funny. It would list close to 800 installed packages on my machine. :-D

Consider to comment it out and use

options(width = 52) devtools::session_info()

instead. On my machine:

- Session info -------------------------------------

 setting  value                       

 version  R version 4.1.0 (2021-05-18)

 os       Windows 7 x64 SP 1          

 system   x86_64, mingw32             

 ui       Rgui                        

 language EN                          

 collate  German_Germany.1252         

 ctype    German_Germany.1252         

 tz       Europe/Vienna               

 date     2021-06-09                  



- Packages -----------------------------------------

 package     * version date       lib source        

 boot        * 1.3-28  2021-05-03 [1] CRAN (R 4.1.0)

 bslib         0.2.5.1 2021-05-18 [1] CRAN (R 4.1.0)

 cachem        1.0.5   2021-05-15 [1] CRAN (R 4.1.0)

 callr         3.7.0   2021-04-20 [1] CRAN (R 4.1.0)

 cli           2.5.0   2021-04-26 [1] CRAN (R 4.1.0)

 colorspace    2.0-1   2021-05-04 [1] CRAN (R 4.1.0)

 crayon        1.4.1   2021-02-08 [1] CRAN (R 4.1.0)

 crosstalk     1.1.1   2021-01-12 [1] CRAN (R 4.1.0)

 data.table    1.14.0  2021-02-21 [1] CRAN (R 4.1.0)

 desc          1.3.0   2021-03-05 [1] CRAN (R 4.1.0)

 devtools      2.4.2   2021-06-07 [1] CRAN (R 4.1.0)

 digest        0.6.27  2020-10-24 [1] CRAN (R 4.1.0)

 dplyr         1.0.6   2021-05-05 [1] CRAN (R 4.1.0)

 ellipsis      0.3.2   2021-04-29 [1] CRAN (R 4.1.0)

 fansi         0.5.0   2021-05-25 [1] CRAN (R 4.1.0)

 fastmap       1.1.0   2021-01-25 [1] CRAN (R 4.1.0)

 fs            1.5.0   2020-07-31 [1] CRAN (R 4.1.0)

 generics      0.1.0   2020-10-31 [1] CRAN (R 4.1.0)

 ggplot2     * 3.3.3   2020-12-30 [1] CRAN (R 4.1.0)

 glue          1.4.2   2020-08-27 [1] CRAN (R 4.1.0)

 gtable        0.3.0   2019-03-25 [1] CRAN (R 4.1.0)

 htmltools     0.5.1.1 2021-01-22 [1] CRAN (R 4.1.0)

 htmlwidgets   1.5.3   2020-12-10 [1] CRAN (R 4.1.0)

 httpuv        1.6.1   2021-05-07 [1] CRAN (R 4.1.0)

 httr          1.4.2   2020-07-20 [1] CRAN (R 4.1.0)

 jquerylib     0.1.4   2021-04-26 [1] CRAN (R 4.1.0)

 jsonlite      1.7.2   2020-12-09 [1] CRAN (R 4.1.0)

 later         1.2.0   2021-04-23 [1] CRAN (R 4.1.0)

 lazyeval      0.2.2   2019-03-15 [1] CRAN (R 4.1.0)

 lifecycle     1.0.0   2021-02-15 [1] CRAN (R 4.1.0)

 magrittr      2.0.1   2020-11-17 [1] CRAN (R 4.1.0)

 memoise       2.0.0   2021-01-26 [1] CRAN (R 4.1.0)

 mime          0.10    2021-02-13 [1] CRAN (R 4.1.0)

 munsell       0.5.0   2018-06-12 [1] CRAN (R 4.1.0)

 pillar        1.6.1   2021-05-16 [1] CRAN (R 4.1.0)

 pkgbuild      1.2.0   2020-12-15 [1] CRAN (R 4.1.0)

 pkgconfig     2.0.3   2019-09-22 [1] CRAN (R 4.1.0)

 pkgload       1.2.1   2021-04-06 [1] CRAN (R 4.1.0)

 plotly      * 4.9.3   2021-01-10 [1] CRAN (R 4.1.0)

 prettyunits   1.1.1   2020-01-24 [1] CRAN (R 4.1.0)

 processx      3.5.2   2021-04-30 [1] CRAN (R 4.1.0)

 promises      1.2.0.1 2021-02-11 [1] CRAN (R 4.1.0)

 ps            1.6.0   2021-02-28 [1] CRAN (R 4.1.0)

 purrr         0.3.4   2020-04-17 [1] CRAN (R 4.1.0)

 R6            2.5.0   2020-10-28 [1] CRAN (R 4.1.0)

 Rcpp          1.0.6   2021-01-15 [1] CRAN (R 4.1.0)

 remotes       2.4.0   2021-06-02 [1] CRAN (R 4.1.0)

 rlang         0.4.11  2021-04-30 [1] CRAN (R 4.1.0)

 rprojroot     2.0.2   2020-11-15 [1] CRAN (R 4.1.0)

 rstudioapi    0.13    2020-11-12 [1] CRAN (R 4.1.0)

 sass          0.4.0   2021-05-12 [1] CRAN (R 4.1.0)

 scales        1.1.1   2020-05-11 [1] CRAN (R 4.1.0)

 sessioninfo   1.1.1   2018-11-05 [1] CRAN (R 4.1.0)

 shiny       * 1.6.0   2021-01-25 [1] CRAN (R 4.1.0)

 shinyFiles  * 0.9.0   2020-11-09 [1] CRAN (R 4.1.0)

 testthat      3.0.2   2021-02-14 [1] CRAN (R 4.1.0)

 tibble        3.1.2   2021-05-16 [1] CRAN (R 4.1.0)

 tidyr         1.1.3   2021-03-03 [1] CRAN (R 4.1.0)

 tidyselect    1.1.1   2021-04-30 [1] CRAN (R 4.1.0)

 usethis       2.0.1   2021-02-10 [1] CRAN (R 4.1.0)

 utf8          1.2.1   2021-03-12 [1] CRAN (R 4.1.0)

 vctrs         0.3.8   2021-04-29 [1] CRAN (R 4.1.0)

 viridisLite   0.4.0   2021-04-13 [1] CRAN (R 4.1.0)

 withr         2.4.2   2021-04-18 [1] CRAN (R 4.1.0)

 xtable        1.8-4   2019-04-21 [1] CRAN (R 4.1.0)

 yaml          2.2.1   2020-02-01 [1] CRAN (R 4.1.0)



[1] D:/Program Files/R/R-4.1.0/library

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Laszlo Istvan Orosz ☆ Hungary, 2021-06-11 11:51 (1819 d 01:25 ago) @ Helmut Posting: # 22407 Views: 5,567	DDSolver Issue Post reply
	Helmut, i have found an easy way to calculate the variance.covariance matrix: https://stattrek.com/matrix-algebra/covariance-matrix.aspx Calcualting the matrix with this way, the result is same like excel data anaysis toolpak. "The method dependet approaches" calculates an other result. I hope, DDSolver calculates correct as well, but i don't know ddsolver uses some other factors as well.

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