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sandeep reddy ☆ India, 2013-07-09 12:57 (4723 d 06:39 ago) Posting: # 10967 Views: 4,379 |
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Dear all can any one help me regarding the study design with three treatments (T1, T2, R) in two period cross over design. can we go for three treatment four sequence cross overdesign Edit: Category changed. [Helmut] |
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d_labes ★★★ Berlin, Germany, 2013-07-09 13:55 (4723 d 05:42 ago) @ sandeep reddy Posting: # 10968 Views: 3,571 |
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Dear sandeep! ❝ can any one help me regarding the study design with three treatments (T1, T2, R) in two period cross over design. Do you really mean such a design? It would be a very unusual design. Usually a three treatment BE study is done as a 3x3x3 (3-treatment-3-sequence-3-period) or 3x6x3 crossover design. Search the forum to find many posts regarding these designs. If you really need a 3-treatment-2-period design (out of curiosity I would know why) I recommend you Chapter 2 of S-C Chow and J-P Liu Design and Analysis of Clinical Trials John Wiley & Sons, Chichester (2009 Third edition) which deals with Balanced Incomplete Block Designs (BIBD). — Regards, Detlew |
Ing. Helmut Schütz