jag009
★★★

NJ,
2013-05-22 17:33
(4771 d 08:51 ago)

Posting: # 10617
Views: 3,729
 

 Impact of dosing scheme on stats [General Sta­tis­tics]

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Hi everyone,

Question... If a clinic set ups the dosing schedule to dose a set of 4 subjects at a time,would there be an impact in the ANOVA model (i.e., group effect)?

Example, n=20 subjects with 4 subjects being dosed at the same time, dosing time between group is 2 min.

Time     Subject
0       1  2  3  4
2min    5  6  7  8
4min    9 10 11 12
6min   13 14 15 16
8min   17 18 19 20

Thanks
John
 
ElMaestro
★★★

Denmark,
2013-05-22 18:12
(4771 d 08:12 ago)

@ jag009
Posting: # 10618
Views: 2,916
 

 Impact of dosing scheme on stats

Post reply
Hi John,

❝ Question... If a clinic set ups the dosing schedule to dose a set of 4 subjects at a time, would there be an impact in the ANOVA model (i.e., group effect)?

❝

❝ Example, n=20 subjects with 4 subjects being dosed at the same time,dosing time between group is 2 min.


I would say no to a group effect in the ANOVA in that example. It appears rather theoretical. In practice I think it often runs like that or some variation of it. In addition, for this type of group effect the issue is between-subjects rather than within so there should be no impact on the BE evaluation in xovers.
—
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ElMaestro
 
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