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vish14184 ★ India, 2007-11-15 12:05 (6390 d 21:11 ago) Posting: # 1297 Views: 9,409 |
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We are planning a replicate study wherein the total blood loss is 480ml in 4 Periods with wash out period of one week between periods. Do you know of any guideline which says that we need to check the Hb (hemoglobin) of the subjects before the start of Period III, please advice. The eligibility criteria before start of study is at least 13.5 Hb. -- Edit: Category changed. [HS] |
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Helmut ★★★   Vienna, Austria, 2007-11-15 16:53 (6390 d 16:24 ago) @ vish14184 Posting: # 1299 Views: 7,530 |
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Dear Vishal, since you have agreed with the forum's policy during registration, you do remember following lines for sure: It's nice to start your post with a salutation, and include a signature as well. You may save a signature with your User's data; it will be automatically attached to your posts. ❝ … total blood loss is 480ml in 4 Periods with wash out period of one week between periods. ❝ Do you know of any guideline which says that we need to check the Hb (hemoglobin) of the subjects before the start of Period III. No guideline I know of. Generally blood loss comparable to a single bood donation (500 mL) in a 2-period study does not rise medical/ethical concerns. IMHO your planned design should not be problematic. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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M.Vasu ★ India, 2007-11-17 05:31 (6389 d 03:45 ago) @ vish14184 Posting: # 1304 Views: 7,424 |
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Hi Vishal, As per American Red Cross, donate at a time at least 110pounds of blood. In India, blood loss is more than 350ml it's required to do HB% regarding subjects safety & ethical concerns. -- Edit: Full quote removed - like in all your previous posts! Please see this post! [HS] |
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Jaime_R ★★ Barcelona, 2007-11-17 15:10 (6388 d 18:06 ago) @ M.Vasu Posting: # 1305 Views: 7,669 |
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Hi vasu! ❝ As per American Red Cross, donate at a time at least 110pounds of blood. ≥110 Pounds?!  According to the American Red Cross 1 US Pint (wet) = 473.176473 mL; 1 Pint (metric) = 500 mL (informally). ❝ In India, blood loss is more than 350ml it's required to do HB% regarding subjects safety & ethical concerns. Do you have a reference? — Regards, Jaime |
Ing. Helmut Schütz