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KellyH ☆ Ireland, 2012-03-16 14:47 (4786 d 06:03 ago) Posting: # 8286 Views: 4,244 |
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Good Day Everyone from Oz! I have an immediate release in vivo profile which has a dose (100mg) administered at 0h and then a subsequent dose (100mg) administered at 8 h (after the first dose) - does anyone have / know of a software program (freeware if possible!!) which is able to estimate a unit impulse response based on this complex profile? Thanks in advance, Kelly H |
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Helmut ★★★   Vienna, Austria, 2012-03-16 16:58 (4786 d 03:52 ago) @ KellyH Posting: # 8287 Views: 3,615 |
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Hi Kelly! ❝ Good Day Everyone from Oz! Hey didn’t know that Ireland = Oz! ❝ I have an immediate release in vivo profile which has a dose (100mg) administered at 0h and then a subsequent dose (100mg) administered at 8 h (after the first dose) - does anyone have / know of a software program (freeware if possible!!) which is able to estimate a unit impulse response based on this complex profile? Hhm. No SW I know of can handle multiple dose profiles. For some freeware see this post and following. Do you have residual concentrations from the first dose at 8 hours? If yes this will be tricky indeed. Maybe you can setup a PK model the first administration, subtract estimated concentrations from the second part of the profile and treat the second administration separately? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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KellyH ☆ Ireland, 2012-03-17 00:46 (4785 d 20:04 ago) @ Helmut Posting: # 8289 Views: 3,680 |
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❝ ❝ Good Day Everyone from Oz! ❝ ❝ Hey didn’t know that Ireland = Oz! That should have been Good Day to Everyone IN Oz!!! My project supervisor told me this site was based in Australia!!! But I see you are in Austria so he was way wrong Austria not Australia!!!  Thanks a million for the reply ❝ ❝ I have an immediate release in vivo profile which has a dose (100mg) administered at 0h and then a subsequent dose (100mg) administered at 8 h (after the first dose) - does anyone have / know of a software program (freeware if possible!!) which is able to estimate a unit impulse response based on this complex profile? ❝ ❝ Hhm. No SW I know of can handle multiple dose profiles. For some freeware see this post and following. Thanks for the software link - us poor students are always on the look out for freeware!! I will pass it on!! ❝ Do you have residual concentrations from the first dose at 8 hours? If yes this will be tricky indeed. Maybe you can setup a PK model the first administration, subtract estimated concentrations from the second part of the profile and treat the second administration separately? Yes we have trailing levels and my supervisor suggested posting here in case you guys knew of some options! Thanks again!! Kel  |
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Helmut ★★★ Vienna, Austria, 2012-03-17 01:19 (4785 d 19:31 ago) @ KellyH Posting: # 8290 Views: 3,631 |
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Hi Kelly! ❝ […] My project supervisor told me this site was based in Australia!!! Oh boy! ![[image]](img/uploaded/image88.png) ❝ Thanks for the software link - us poor students are always on the look out for freeware!! I will pass it on!! Freeware rulez! Have you ever tried to find the person responsible for a particular function in commercial software? If debugging is the process of removing bugs, — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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SDavis ★★ UK, 2012-04-17 13:41 (4754 d 08:09 ago) @ KellyH Posting: # 8428 Views: 3,447 |
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Hi Kelly, If you go to the bottom of this page; you or your supervisor can enquire about our academic licensing options. http://pharsight.com/products/prod_ivivc_toolkit_order.php Simon. — Simon Senior Scientific Trainer, Certara™ [link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link] https://www.certarauniversity.com/dashboard https://support.certara.com/forums/ |
Ing. Helmut Schütz