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ioanam ★ Romania, 2010-11-23 14:48 (5265 d 01:49 ago) Posting: # 6197 Views: 5,815 |
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Dear all, please give me an advice related to the most appropriate software to be used (except PROC GLM in SAS) for statistical analysis in a replicate crossover study. Can you tell me if ANOVA in Kinetica software is a good choice? Thank you. |
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Helmut ★★★   Vienna, Austria, 2010-11-23 16:25 (5265 d 00:12 ago) @ ioanam Posting: # 6201 Views: 5,109 |
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Dear Jo! ❝ Can you tell me if ANOVA in Kinetica software is a good choice? Hey, we had that already.  The answer is no.Phoenix/WinNonlin is an alternative (we checked an example dataset assesed by FDA's SAS-code at Pharsight's Extranet) - but I would wait until EMA publishes their SAS-code for replicate studies (which will include a sample dataset). — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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ioanam ★ Romania, 2010-11-23 16:39 (5264 d 23:59 ago) @ Helmut Posting: # 6202 Views: 4,998 |
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Dear Helmut! I forgot about this post and I have some data that I can not evaluate. So, I'm trying to find solution. Thank you very much for remembering me  Ioana |
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Helmut ★★★ Vienna, Austria, 2010-11-23 16:47 (5264 d 23:50 ago) @ ioanam Posting: # 6204 Views: 5,018 |
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Dear Ioana! ❝ I'm trying to find solution. If you don’t want to purchase Phoenix/WinNonlin consider package bear for R (freeware). For some related discussions browse the forum’s category R for BE/BA. The developers (Hsin-ya Lee & Yung-jin Lee) are active members of the forum… ❝ Thank you very much for remembering me How could I forget you? — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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ioanam ★ Romania, 2010-11-23 16:43 (5264 d 23:54 ago) @ Helmut Posting: # 6203 Views: 4,984 |
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Dear Helmut do you think that EMA will publish SAS for replicate studies? Thank you again |
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Helmut ★★★ Vienna, Austria, 2010-11-23 16:50 (5264 d 23:47 ago) @ ioanam Posting: # 6206 Views: 5,014 |
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Dear Ioana! ❝ do you think that EMA will publish SAS for replicate studies? Definitely yes. Last month in Munich two members of the PK group told me that the document is already finalized – we are all waiting for being published at EMA’s website. Edit: Published 14 Mar 2011 (see here). [Helmut] — Dif-tor heh smusma 🖖🏼 Довге життя Україна! Helmut Schütz The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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d_labes ★★★ Berlin, Germany, 2010-11-23 16:49 (5264 d 23:48 ago) @ ioanam Posting: # 6205 Views: 5,038 |
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Dear Io, replicate designs were handled in SAS usually by calling Proc MIXED, not Proc GLM. Beside commercial software like Helmut's recommendation you can try R's add-on package nlme, function lme() or use bear which has implemented the evaluation of replicate studies (but only 2-sequence replicate crossover designs). via lme(). The estimates of the parameters of interest, namely the difference T-R and the intra-individual variabilities, are the same as in SAS, FDA code. But the degrees of freedom for the effects tested are different and therefore also the 90% confidence intervals derived. See this thread for a discussion. With 'enough' subjects the difference is usually not so marked. But don't know how the regulatory acceptance is. Hope this helps. — Regards, Detlew |
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ioanam ★ Romania, 2010-11-23 17:11 (5264 d 23:26 ago) @ d_labes Posting: # 6207 Views: 5,013 |
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Thank you all for helping me everytime! Ioana |
Ing. Helmut Schütz