Bioequivalence and Bioavailability Forum • IVIVC Data Set Entry and Calculation

ramesh_7779
★

2010-06-26 07:56
(5415 d 07:02 ago)

Posting: # 5565
Views: 5,547

IVIVC Data Set Entry and Calculation [Software]

Dear All,

Can anyone tell me whether the data format for IVIVC calculation by Winnonlin is correct or not? If not please correct me. Because I'm facing problem when I click 'Deconvolve' in vivo tab. Please find the error below.

"Error creating temporary input workbook for deconvolution. Incomplete UIR-Sort Key matching, Ensure all sort levels have an associated reference formulation"

Formulation:

Immeditae - CR01
Slow - CR02
Fast -CR03

No external validation batch

IVIVC_DISS.PWO (Data set for In vitro tab)


Form    Time(hr)    Fdiss

CR01    0            0

CR01    0.5         35.62

CR01    1           40.23

CR01    1.5         51.02

CR01    2           57.32

CR02    0            0

CR02    0.5         13.13

CR02    1           17.86

CR02    1.5         23.08

CR02    2           26.58

IVIVC_VIVO_SUBJ.PWO (Data set for In vivo tab)


Subject  Form     Time(hr)       Fdiss

1        CR03     0              0

1        CR03     0.5            4.807

1        CR03     1              9.375

1        CR03     1.5            12.83

1        CR03     2              15.872

IVIVC_TEST.PWO (Data set for Correlation tab)


Form    Time(hr)    Fdiss

CR01    0            0

CR01    0.5         35.62

CR01    1           40.23

CR01    1.5         51.02

CR01    2           57.32

If i made any enty in Data entry correct me. Help me to solve the problem and guide me to complete my calcualtion.

With Regards
Raja

Edit: Category changed, 'tables' BBCoded. [Helmut]

SDavis
★★

UK,
2010-07-02 17:17
(5408 d 21:42 ago)

@ ramesh_7779
Posting: # 5585
Views: 4,311

IVIVC Data Set Entry and Calculation

Post reply

Raja,

From the data you present the problem appears to be that you have;

in vitro data for;

❝ Immediate - CR01

❝ Slow - CR02

but for IN VIVO data you have only

❝ Fast -CR03

and then your IVIVC_TEST.PWO (which I assume to be your 'new' formulation that you want to predict PK, is called CR01

I think this is why you are getting the message;
"Error creating temporary input workbook for deconvolution. Incomplete UIR-Sort Key matching, Ensure all sort levels have an associated reference formulation"

i.e. You must have data for IN VITRO and IN VIVO from the same formulation and give it the same name in both sheets. Try naming the formulations as you call them internally; the example data in WNL is CR01 etc. for controlled release.

i.e. you have dissolution and in vivo data for INNOVATOR and TEST1, you now have minimum to build a correlation (more would be better). Then in your *test* data you have a third formulation TEST2, with ONLY DISSOLUTION data in it, this is what you will use to try to predict PK. INNOVATOR would be your REFERENCE (you might have to duplicate that data set)

Simon.

Does that clarify your problem? I think you've had some discussions with my colleagues as #131018

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Simon
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