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KR ★ India, 2009-04-06 09:47 (5871 d 17:47 ago) Posting: # 3478 Views: 4,511 |
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Dear all, Kindly give the guidance about how to do pharmacodynamic analysis using WinNonlin software. Moreover, how to do statistical analysis of pharmacodynamic parameters? For your information, the drug is used to treat hypertension and congestive heart failure. Waiting for your valuable reply. Kaushal Raval |
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Helmut ★★★   Vienna, Austria, 2009-04-06 15:50 (5871 d 11:44 ago) @ KR Posting: # 3486 Views: 3,794 |
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Dear Kaushal! ❝ Kindly give the guidance about how to do pharmacodynamic analysis using ❝ WinNonlin software. I expect you to do your homework first (RTFM and WinNonlin's 'Examples Guide'). What specific problems do you face? ❝ Moreover, how to do statistical analysis of pharmacodynamic parameters? ❝ For your information, the drug is used to treat hypertension and ❝ congestive heart failure. More information please. Are you comparing treatment with placebo or a standard treatment? F.i. differences in blood pressure may be used (mm Hg, linear model)... — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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SDavis ★★ UK, 2009-04-06 23:03 (5871 d 04:30 ago) @ KR Posting: # 3487 Views: 3,882 |
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Further to Helmut's comments, these User and Examples guides can typically be found in the install directory e.g. C:\\Program Files\\Pharsight\\WinNonlin\\User Docs. Please look at page 57 of the examples guide if you are interested in a worked example of the new (from version 5.0) NCA model 220 for PD. Cheers, Simon. ___________________________________ Forthcoming meetings and training http://www.pharsight.com/training; http://www.page-meeting.org: 23-26 June 2009 Saint Petersburg, Russia Transitioning to WinNonlin v6.0: 30 June Munich, Germany Introduction to WinNonlin v6.0: 1-3 July Munich, Germany |
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KR ★ India, 2009-04-07 11:02 (5870 d 16:32 ago) @ SDavis Posting: # 3490 Views: 3,717 |
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Dear Helmut and Simon, Thank you for the answer. We are going to compare test vs. reference and it's a multiple dose study of 5 days and BE criteria is applicable for 5th day and sampling upto 24 hours for the 5th day. In this study, PK and PD both will be done. Now, how can i do statistical analysis based on the information? Thanks in advance, KR |
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SDavis ★★ UK, 2009-04-08 14:01 (5869 d 13:33 ago) @ KR Posting: # 3500 Views: 3,732 |
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Hi Kaushal, again I would suggest you review your data and identify what you are comparing? PK? PD? both? Typically Cmax and AUC might be compared in e.g. the BE Wizard, however if you wanted to select some other parameter e.g. Tmin and Rmin (time of, and minimum effect seen, since I imagine you are seeking a decrease in blood pressure) and put them through that same Wizard (which is in fact a front end for the LinMix engine). You can learn about this from the Examples and User guides - or you could look at attending a training course (perhaps from Pharsight!) if you don't like reading manuals  Simon. — Simon Senior Scientific Trainer, Certara™ [link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link] https://www.certarauniversity.com/dashboard https://support.certara.com/forums/ |
Ing. Helmut Schütz