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thong ☆ 2009-02-06 17:16 (5934 d 23:09 ago) (edited on 2009-02-06 21:11) Posting: # 3191 Views: 5,232 |
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Dear All, Does anyone know if WinNonlin 1. Can do Deconvolution and convolution? 2. Can perform three way replicate design? Thank you and More Power. thong Note: I'm sorry Helmut I missed some words to my number two(2) question. It should be If winnonlin can perform three way Cross over replicate design |
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Helmut ★★★   Vienna, Austria, 2009-02-06 17:39 (5934 d 22:46 ago) @ thong Posting: # 3192 Views: 4,322 |
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Dear thong, ❝ Does anyone know if WinNonlin ❝ 1. Can do Deconvolution and convolution? Only with the IVIVC Toolkit (an add-on which costs about the same as WinNonlin itself). ❝ 2. Can perform three way replicate design? ABE - yes PBE/IBE - yes RSABE - not directly (you have to fiddle around with the output quite a lot - nothing for beginners). ❝ Thank you and More Power. I couldn't stand even more.  — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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SDavis ★★ UK, 2009-02-07 00:35 (5934 d 15:50 ago) @ thong Posting: # 3193 Views: 4,531 |
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Small correction to Helmut's comment WinNonlin Professional on it's own can do Deconvolution (since 3.1), primarily intended for use with a UIR derived from an IV reference. It is a constrained deconvolution method that produces a smooth estimate of the input rate which is constrained to be non-negative. The degree of smoothness may specified by the user. However as Helmut mentioned, for convolution among other functions, Pharsight has built an 'add on', the IVIVC toolkit, that supports your workflows while building, validating and predicting from your correlation model. You can find out more about this module by looking at some of the past event recordings, see below. Best regards, Simon. IVIVC Toolkit for WinNonlin: Product Introduction & Demonstration http://pharsight.com/events/eventsonline_archive.php#replay_009 IVIVC Applications and Case Studies http://pharsight.com/events/eventsonline_archive.php#replay_015 — Simon Senior Scientific Trainer, Certara™ [link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link] https://www.certarauniversity.com/dashboard https://support.certara.com/forums/ |
Ing. Helmut Schütz