Bioequivalence and Bioavailability Forum • Calculating Pharmacodynamic Parameters-Using Kinetica

sasikumar
☆

Tamilnadu, India,
2008-05-26 17:16
(6194 d 06:17 ago)

Posting: # 1871
Views: 5,075

Calculating Pharmacodynamic Parameters-Using Kinetica [Software]

Dear All,

Data for Pharmacological Activity (i.e.Anti-Xa(IU/ml) activity, Prothrombin time) of a particular drug after Subcutaneous injection is available with me.

Kindly clarify whether the above Pharmacological Activity can be calculated using Pharmacokinetic or Pharmacodynamic or both the methods.

What is the basic method for Calculating Pharmacodynamic Parameters Using Kinetica Software?

Immediate reply will help us.

Thanks and Regards,
S.Sasikumar

SDavis
★★

UK,
2008-11-18 18:24
(6018 d 04:09 ago)

@ sasikumar
Posting: # 2721
Views: 4,150

Calculating Pharmacodynamic Parameters-Using Kinetica

Post reply

Dear Dr Sasikumar,
I'm not sure what Pharmacodynamic Parameters you are seeking to calculate. If you want to calculate EMax, EC50 etc I think there is a general pharmacodynamics template supplied in Kinetica but it is a few years since I used it.

Alternatively you could consider using WinNonlin's range of built in PD models;

Model Description                           Effect at C=0 Effect at C=inf

Model 101 Simple Emax Model:                      0             Emax 

Model 102 Simple Emax Model:                     E0             Emax 

Model 103 Inhibitory Effect Emax Model:         Emax              0 

Model 104 Inhibitory Effect Emax Model:         Emax             E0 

Model 105 Sigmoid Emax Model:                     0             Emax 

Model 106 Sigmoid Emax Model:                    E0             Emax 

Model 107 Inhibitory Effect Sigmoid Emax Model: Emax              0 

Model 108 Inhibitory Effect Sigmoid Emax Model: Emax             E0

or Model 220 which is an NCA method for assessing Drug effect data which is available for versions 5 upwards

Best regards,
Simon.
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