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Ravi ★ India, 2008-06-30 14:09 (6156 d 09:56 ago) Posting: # 1986 Views: 5,399 |
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Hi everyone, I m using Winnonlin 5.2 version. In the Model 18 (Three -Compartment with bolus input, first-order output and macro constant as primary parameters) given in user's guide on page 455 one of the input or required constant for calculation is stripping dose. Now My Question is what this stripping dose is? what does it mean. how one should define its value. Is it drug specific. Please give full details if possible. Any help will be highly appreciated. Thanks & Regards Ravi Pandey — Thanks & Regards Ravi Pandey |
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Helmut ★★★   Vienna, Austria, 2008-06-30 15:49 (6156 d 08:16 ago) @ Ravi Posting: # 1987 Views: 12,203 |
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Dear Ravi, ❝ Now My Question is what this stripping dose is? what does it mean. From p 516 of the User's Guide: Dose associated with initial parameter estimates for macro constant models. In these models, which can be written as a sum of exponentials, dose does not appear explicitly in the model. Rather, the macro constants are a function of dose. Thus, when fitting macro constant models with user-specified initial estimates, the user must specify the associated dose. For single dose macro constant models, when WinNonlin determines initial parameter estimates by curve stripping, the stripping dose is identical to the administered dose. It's further explained in pp 502-503 of the User's Guide. ❝ how one should define its value. It's simply the dose administered. ❝ Is it drug specific. No. A dose is a dose is a dose. (interpreting Gertrude Stein) — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz