Bioequivalence and Bioavailability Forum

libaiyi ★ China, 2018-07-03 11:42 (2906 d 14:01 ago) Posting: # 19008 Views: 5,508	Intra-CV in three-treatment, three-period, three-sequence study in SAS [Software] Post reply
	Hi, When I try to calculate the intra-CV of three-treatment, three-period, three-sequence study in SAS, there is only one residual in the output. So, how could I find out the intra-CV between T1-R and T2-R respectively? Could I put only T1 and R or T2 and R in the model to get intra-CV respectively to compare which treatment is better? Thanks in advance.

Helmut
★★★

Vienna, Austria,
2018-07-03 13:26
(2906 d 12:18 ago)

@ libaiyi
Posting: # 19010
Views: 4,569

ISCVs of T1-R and T2-R: Leave-One-Out (IBD)

Post reply

Hi libaiyi,

❝ When I try to calculate the intra-CV of three-treatment, three-period, three-sequence study in SAS, there is only one residual in the output.

Correct – if you use the conventional model, you get only one (pooled) variance.

❝ So, how could I find out the intra-CV between T1-R and T2-R respectively? Could I put only T1 and R or T2 and R in the model to get intra-CV respectively to compare which treatment is better?

See this post. You are on the right track. :-)

Perform two analyses, where in the first you exclude T2 and in the second T1.

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Intra-CV in three-treatment, three-period, three-sequence study in SAS [Software]

ISCVs of T1-R and T2-R: Leave-One-Out (IBD)