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sunny ☆ 2014-04-16 00:18 (4024 d 10:45 ago) Posting: # 12844 Views: 4,685 |
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Dear all, I am a beginner in this field and this site is great to learn! I tried to use Phoenix to simulate BE trials to evaluate the BE of two formulations. My Phoenix does have NLME package, but I don't know how to enter the trial design feature into the simulation mode. Any help will be greatly appreciated. Also, after simulating 100 trials (with 24 subjects for each trial), is there an easy to send all those trials to Pheonix for NCA analysis? Manually sending one trial after one sounds a little scaring  Thanks for your time and help in advance  Sunny |
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jag009 ★★★ NJ, 2014-04-21 17:19 (4018 d 17:44 ago) @ sunny Posting: # 12867 Views: 3,752 |
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Hi Sunny, ❝ I tried to use Phoenix to simulate BE trials to evaluate the BE of two formulations. My Phoenix does have NLME package, but I don't know how to enter the trial design feature into the simulation mode. Any help will be greatly appreciated. Also, after simulating 100 trials (with 24 subjects for each trial), is there an easy to send all those trials to Pheonix for NCA analysis? Manually sending one trial after one sounds a little scaring Are you using Phoenix itself to simulate the trials (I think one module has that capability?) or you run your trials and then import the data into Phoenix? John |
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SDavis ★★  UK, 2014-04-24 16:25 (4015 d 18:38 ago) @ sunny Posting: # 12888 Views: 3,795 |
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Sunny, If you have indeed simulated the trials in Phoenix then you could in fact request the NCA 'end points' within the same PML e.g. if you want AUC_t1 to t2 you can add an ODE to the model and capture the value at t2 in a table statement; e.g. #deriv(AUCt = (t>t1)*(t<t2)*C) deriv(AUCt = (t>0)*(t<999)*C) see this post here; http://www.pharsight.com/extranet/index.php?option=com_kunena&Itemid=55&func=view&catid=40&id=1359&limit=6&limitstart=6#1716 You could also post your question and project there which would probably give you some tips from our own consultants as well as other users. Simon — Simon Senior Scientific Trainer, Certara™ [link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link] https://www.certarauniversity.com/dashboard https://support.certara.com/forums/ |
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