Harish Kaushik
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India,
2012-05-21 12:52
(5148 d 02:58 ago)

Posting: # 8592
Views: 4,696
 

 Polynomial UIR [Dissolution / BCS / IVIVC]

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Hello HS,
Iam novice in the field of IVIVC and Iam trying to understand the background of using Polynomial UIR function for deconvolution from PO &IV Bolus data.
What is the significance of increasing exponentials from 2(bi),3(tri),... etc for predicting the absorption profile of the drug

Please can you elaborate me !!

Regards
Harish Kaushik
 
SDavis
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UK,
2012-05-21 14:36
(5148 d 01:14 ago)

@ Harish Kaushik
Posting: # 8594
Views: 3,789
 

 Polynomial UIR

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Harish, the significance of increasing exponentials, is to reflect the number of compartments you see in the 'reference' data e.g. if IV-2com model gives the best fit of your data then you will use that estimation of the elimination to deconvolve your oral profile.

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