drcampos
★    

Brazil,
2008-09-09 05:34
(6497 d 22:13 ago)

Posting: # 2339
Views: 6,870
 

 Deconvolution [Dissolution / BCS / IVIVC]

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Dear All,

I would like to know why in a deconvolution procedure (Wagner Nelson or Loo Riegelman) the 100% of fraction absorbed is not achieved in Tmax? For example, plasma concentration versus time figure with Tmax = 3h and fraction absorbed versus time figure with 100% absorved in 8h (only 60 - 70% in 3h (Tmax).

Thank you in advance.

Daniel Rossi de Campos
Brazil
 
Ohlbe
★★★

France,
2008-09-09 19:22
(6497 d 08:25 ago)

@ drcampos
Posting: # 2344
Views: 5,499
 

 Deconvolution

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Dear Dr de Campos,

I am not a specialist in this field. But could the answer have a link with this discussion ? (See in particular my message and Helmut's response to it).

Regards
Ohlbe
 
drcampos
★    

Brazil,
2008-09-09 23:14
(6497 d 04:33 ago)

@ Ohlbe
Posting: # 2345
Views: 5,534
 

 Deconvolution

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Dear Ohlbe,

Merci beaucoup! Your message and Helmut's response were perfect for the question about Tmax and t1/2! The discussion and examples answered my question.

regards,

Daniel Rossi de Campos
Brazil
 
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