Ahikal
☆    

Egypt,
2021-12-24 18:41
(1623 d 02:20 ago)

Posting: # 22716
Views: 5,509
 

 dissolution, passing f2 but failing f1 [Dissolution / BCS / IVIVC]

hello all, in a dissolution comparison, I got f2>50, f1>15, and within batch CV<15%. I am befuddled, would appreciate any suggestion.
thanks
Ahmed
dshah
★★  

India,
2021-12-29 11:28
(1618 d 09:32 ago)

@ Ahikal
Posting: # 22719
Views: 4,333
 

 dissolution, passing f2 but failing f1

Hello Ahmed!
Could you provide details for %CV? it seems that the dissolution is having higher %SD apart from 1st time point. Kindly try to evaluate other methods like Bootstrap/MSD.
Regards,
Dshah
UA Flag
Activity
 Admin contact
23,653 posts in 4,991 threads, 1,570 registered users;
133 visitors (0 registered, 133 guests [including 42 identified bots]).
Forum time: 22:01 CEST (Europe/Vienna)

I’m all in favor of the democratic principle
that one idiot is as good as one genius, but I draw the line
when someone takes the next step and concludes
that two idiots are better than one genius.    Leo Szilard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5