Ionsource
☆    

Pakistan,
2016-03-22 12:54
(3740 d 05:49 ago)

Posting: # 16127
Views: 4,360
 

 Using IVIVC data of different salts and strengths of diclo­fenac [Dissolution / BCS / IVIVC]

Post reply
Dear All,

I would be grateful if I could get answers to following queries,
  1. Can 100 mg diclofenac sodium IVIVC data be used to predict the in-vivo performance of 100 mg diclofenac potassium formulation?
  2. If we have IVIVC data for 50 mg diclofenac potassium, can it be used for 100 mg formulation given that the excipients are also different?

I need to develop a research formulation and could not find a satisfactory answer in the literature that's why i need guidance in this regard.

thanks and regards
 
UA Flag
Activity
 Admin contact
23,654 posts in 4,992 threads, 1,570 registered users;
169 visitors (0 registered, 169 guests [including 17 identified bots]).
Forum time: 19:44 CEST (Europe/Vienna)

“Data! Data! Data!” he cried impatiently.
“I can’t make bricks without clay!”    Arthur Conan Doyle

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5