Bhupesh
☆    

India,
2008-01-04 11:16
(6739 d 20:15 ago)

Posting: # 1467
Views: 6,706
 

 Dissolution profile estimation [Dissolution / BCS / IVIVC]

Dear All
Regards
I want to ask if there is any method through which we can guess the in vitro release profile of the product depending upon the in vivo results (plasma concentration time profile).
Thanks
SDavis
★★  
Homepage
UK,
2009-01-15 12:04
(6362 d 19:27 ago)

@ Bhupesh
Posting: # 3037
Views: 4,887
 

 Dissolution profile estimation

I am sure you can do this by rearranging one of the correlation model equations once you had built a correlation - but I guess my question would be why? dissolution experiments are normally much cheaper (and quicker) than in vivo experiments.

Simon
Senior Scientific Trainer, Certara™
[link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link]
https://www.certarauniversity.com/dashboard
https://support.certara.com/forums/
UA Flag
Activity
 Admin contact
23,654 posts in 4,992 threads, 1,571 registered users;
204 visitors (0 registered, 204 guests [including 49 identified bots]).
Forum time: 08:31 CEST (Europe/Vienna)

“Data! Data! Data!” he cried impatiently.
“I can’t make bricks without clay!”    Arthur Conan Doyle

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5