Bhupesh
☆    

India,
2008-01-04 11:16
(6749 d 09:06 ago)

Posting: # 1467
Views: 6,726
 

 Dissolution profile estimation [Dissolution / BCS / IVIVC]

Dear All
Regards
I want to ask if there is any method through which we can guess the in vitro release profile of the product depending upon the in vivo results (plasma concentration time profile).
Thanks
SDavis
★★  
Homepage
UK,
2009-01-15 12:04
(6372 d 08:18 ago)

@ Bhupesh
Posting: # 3037
Views: 4,906
 

 Dissolution profile estimation

I am sure you can do this by rearranging one of the correlation model equations once you had built a correlation - but I guess my question would be why? dissolution experiments are normally much cheaper (and quicker) than in vivo experiments.

Simon
Senior Scientific Trainer, Certara™
[link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link]
https://www.certarauniversity.com/dashboard
https://support.certara.com/forums/
UA Flag
Activity
 Admin contact
23,655 posts in 4,993 threads, 1,571 registered users;
362 visitors (0 registered, 362 guests [including 18 identified bots]).
Forum time: 21:22 CEST (Europe/Vienna)

Don’t compromise yourself.
You are all you’ve got.    Janis Joplin

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5