Karthik
☆    

Chennai,
2011-03-17 11:17
(5157 d 04:30 ago)

Posting: # 6769
Views: 8,439
 

 manual power calculation [Power / Sample Size]

how to calculate power without using any software? or what are all the parameters we want consider to calculate power?


Edit: Category and subject line changed. [Helmut]

regards,
karthik
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2011-03-28 16:40
(5146 d 00:07 ago)

@ Karthik
Posting: # 6824
Views: 7,474
 

 manual power calculation: why?

Dear Karthik!

❝ how to calculate power without using any software?


At least you need a pocket calculator and tables of the t-distribution. ;-)

For approximations see

Hauschke D, Steinijans VW, Diletti E and M Burke
Sample Size Determination for Bioequivalence Assessment Using a Multiplicative Model
J Pharmacokin Biopharm 20/5, 557-561 (1992)


Why don’t you use free software (FARTSSIE for Excel, package PowerTOST for R)?

❝ or what are all the parameters we want consider to calculate power?


With given α (patient’s risk, commonly 5%), acceptance range (commonly 80–125%), expected T/R-ratio, and sample size you get power.
If you want to calculate sample size for target power (e.g., 80%), increase the sample size until calculated power ≥ target power. Sample size calculation is always an iterative procedure. See one of my presentations.
K2K
★    

India,
2012-01-16 13:56
(4852 d 01:51 ago)

@ Helmut
Posting: # 7943
Views: 6,251
 

 manual power calculation: why?

dear sir

❝ At least you need a pocket calculator and tables of the t-distribution. ;-)


with the help of EXCEl sheet we can able to calculate power? if possible means advice me how to calculate.

Sample Size Calculations
…or the Myth of Power

thanks and regards
Karthik
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2012-01-16 14:14
(4852 d 01:33 ago)

@ K2K
Posting: # 7945
Views: 6,790
 

 FARTSSIE.xls

Dear Karthik!

❝ with the help of EXCEl sheet we can able to calculate power?


Sure. Get David Dubins’ FARTSSIE.xls 1.7. You have to allow the execution of macros at startup.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
K2K
★    

India,
2012-01-16 14:21
(4852 d 01:26 ago)

@ Helmut
Posting: # 7946
Views: 6,585
 

 FARTSSIE.xls

Dear sir!

thanks

without using that FARTSSIE.xls software with manual calculation from excel its possible to calculate power.

http://bebac.at/lectures/Mumbai-BEWS2011-4.pdf

in that pdf lecture page of 14 i try to calculate MSE but i didnt get the correct value sir but without multiply of 2 *(delcL/sqrt*tdist)^2

whether 2* (----) will come or not

thanks you
karthik

thanks and regards
Karthik
Helmut
★★★
avatar
Homepage
Vienna, Austria,
2012-01-16 15:27
(4852 d 00:21 ago)

@ K2K
Posting: # 7949
Views: 6,596
 

 CV from CI: manual, PowerTOST, FARTSIE.xls

Dear Karthik!

Strange. In the following all intermediate steps (rounded values from the presentation and full internal precision; CLlo 0.91, CLhi 1.15, n1 11, n2 10):

            rounded   full prec.
PE           1.023     1.022986
∆CL          0.11702   0.117036
(numerator)
t            1.729     1.729131
denominator  0.755450  0.755512
num/denom    0.154911  0.154910
squared      0.023990  0.023997
MSE          0.047980  0.047994
(squared ×2!)
CV           22.2%    22.1731%

Quite close to R package PowerTOST:
require(PowerTOST)
100*CVfromCI(lower=0.91, upper=1.15, n=21, design = "2x2", alpha = 0.05)
[1] 22.19886


FARTSSIE.xls (Bioequivalence, Crossover) ISV from Published Point Estimate and CI:
NA, 0.91, 1.15, 90, 21 ⇒ ISV = 22.2%

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
K2K
★    

India,
2012-01-18 10:35
(4850 d 05:13 ago)

@ Helmut
Posting: # 7958
Views: 6,287
 

 CV from CI: manual, PowerTOST, FARTSIE.xls

dear sir

i calculated N=28 (sqrt(1/28+1/28))

so only i didnt get sir

sorry and thanks for your vauable reply

thanks and regards
Karthik
UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,668 registered users;
38 visitors (0 registered, 38 guests [including 6 identified bots]).
Forum time: 16:48 CEST (Europe/Vienna)

The whole purpose of education is
to turn mirrors into windows.    Sydney J. Harris

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5