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Phaneendra.K ☆ 2011-03-10 13:39 (5582 d 14:30 ago) Posting: # 6738 Views: 5,941 |
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Hello, Intrasubject variability. Is this expected value or calculated. How does this parameter have pertinence in study performance. — Thanks and Regards, PK |
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Helmut ★★★   Vienna, Austria, 2011-03-10 13:50 (5582 d 14:19 ago) @ Phaneendra.K Posting: # 6741 Views: 4,926 |
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Hi Phani! ❝ Intrasubject variability. Is this expected value or calculated. Since you posted in the Sample Size category: It's one of the four fixed values (α, acceptance range, T/R-ratio, CV). Based on those you calculate power (1–β). ❝ How does this parameter have pertinence in study performance. In the study itself, none. But since the value is based on MSE, the higher the CV for any given sample size, the wider the confidence interval. |
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Alpesh Ramani ☆ Ahmedabad, India, 2011-03-14 10:10 (5578 d 17:59 ago) @ Helmut Posting: # 6756 Views: 5,039 |
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Dear HS, Intrasubject CV is molecule property or its' also affected by formulation property? For different strengh of same molecule observed with different % CV and repeat study with same strength also observed with different study. As everybody know that % CV is used to calculate the sample size. So it is always a matter of confusion with % CV take for sample size calculation for next study, i.e., First pilot, recent study or literature based CV. Kindly provide your valuable inputs with this regards. — Alps |
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ElMaestro ★★★ Denmark, 2011-03-14 10:19 (5578 d 17:50 ago) @ Alpesh Ramani Posting: # 6757 Views: 4,784 |
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Hello Alpesh Ramani, ❝ Intrasubject CV is molecule property or its' also affected by formulation property? Both. ❝ As everybody know that % CV is used to calculate the sample size. So it is always a matter of confusion with % CV take for sample size calculation for next study, i.e., First pilot, recent study or literature based CV. There is no easy answer. I would use the CV-value that appears most trustworthy from your source material. Age of study, apparent standard of conduct, and N would all play a role. I would not pool studies, but that of course is a personal and subjective comment. — Pass or fail! ElMaestro |
Ing. Helmut Schütz