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earlybird ☆ 2009-12-07 10:14 (6037 d 00:50 ago) (edited on 2009-12-07 12:11) Posting: # 4436 Views: 4,839 |
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Dear all, imagine a 4-sequence, 4-period, 4 treatment crossover study as described in the Canadian guideline „Guidance to establish equivalence or relative potency of safety and efficacy of a second entry short-acting beta 2- agonist metered dose inhaler“. According Richard C. Ahrens et. al. for example “Asthma Stability after Oral prednisone” sample size depends on the ratio of slope and variability. Does anybody knows how to calculate sample size for relative potency, in crossover or parallel group studies ? Best regards, earlybird -- Edit: Category and subject line changed. [Jaime] |
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Helmut ★★★   Vienna, Austria, 2009-12-07 16:07 (6036 d 18:57 ago) @ earlybird Posting: # 4437 Views: 3,947 |
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Dear earlybird! ❝ According Richard C. Ahrens et. al.... ❝ Does anybody knows how to calculate sample size for relative potency, in crossover or parallel group studies ? Not me.  Did you consider asking Richard Ahrens? He is a nice guy.— Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
Ing. Helmut Schütz