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Imph ★ 2022-01-23 15:21 (1189 d 03:24 ago) Posting: # 22743 Views: 3,465 |
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Hello, Please I have a question regarding the within subject coefficient of variation. Is it dose dependent? Can I take a coefficient of variation from a study done on a 500mg dosage and use it to calculate the number of subjects in a trial that will be done on a 1000mg dosage. Thank you in advance. |
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Helmut ★★★   Vienna, Austria, 2022-01-23 15:46 (1189 d 02:59 ago) @ Imph Posting: # 22744 Views: 2,776 |
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Hi Imph, ❝ […] within subject coefficient of variation. Is it dose dependent? If you have linear PK, generally yes. Otherwise, not necessarily. ❝ Can I take a coefficient of variation from a study done on a 500mg dosage and use it to calculate the number of subjects in a trial that will be done on a 1000mg dosage. See above. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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Imph ★ 2022-01-23 15:55 (1189 d 02:50 ago) @ Helmut Posting: # 22745 Views: 2,625 |
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Thank you a lot for your help. Best regards. Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut] |
Ing. Helmut Schütz