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BE-proff ● 2016-11-07 22:53 (3093 d 14:30 ago) Posting: # 16786 Views: 5,537 |
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Hi All, What is/are formula/as used by sampleN.TOST to calculate sample size of different study designs?  I am interested in "exact" method.  |
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Helmut ★★★   Vienna, Austria, 2016-11-07 23:10 (3093 d 14:13 ago) @ BE-proff Posting: # 16787 Views: 4,242 |
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Hi BE-proff, ❝ What is/are formula/as used by sampleN.TOST to calculate sample size of different study designs? ❝ I am interested in "exact" method. See this post and the references. Since numeric integration is involved, it is not that easy. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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d_labes ★★★ Berlin, Germany, 2016-11-08 09:29 (3093 d 03:54 ago) @ BE-proff Posting: # 16788 Views: 4,236 |
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Dear BE-proff, ❝ What is/are formula/as used by sampleN.TOST to calculate sample size of different study designs? ❝ I am interested in "exact" method. additional to Helmut's suggestion I would point you to the \doc sub-directory of the package PowerTOST. It contains a PDF file BE_power_sample_size_excerpt.pdf which deals in a short cursory manner with power / sample size estimation of the TOST procedure.As you will see there is no distinct (simple) formula for sample size estimation. Only the power (given CV and n and additionally some design characteristic) can be calculated. The sample size is then iteratively obtained by varying n until the desired power is achieved. Hope this helps. — Regards, Detlew |
Ing. Helmut Schütz