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mathews ● 2008-02-05 11:09 (6720 d 16:26 ago) Posting: # 1582 Views: 8,782 |
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Hi All, Which CV is used for sample size calculation for a parallel design? inter CV or total CV? How to calculate it from the ANOVA table?. The analysis of a parallel design is same as that of a one way anova with only one factor formulations. Is it right? Regards Matz -- Edit: Category changed. [HS] |
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Helmut ★★★   Vienna, Austria, 2008-02-05 16:35 (6720 d 11:00 ago) @ mathews Posting: # 1588 Views: 7,074 |
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Dear Matz! ❝ Which CV is used for sample size calculation for a parallel design? inter ❝ CV or total CV? Total. ❝ How to calculate it from the ANOVA table?. See this thread. ❝ The analysis of a parallel design is same as that of a one way anova with ❝ only one factor formulations. Is it right? Yes. But for some pitfalls (assumption of equal variances) see this thread, and that one as well. — Dif-tor heh smusma 🖖🏼 Довге життя Україна! ![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png) Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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mathews ● 2008-02-07 06:49 (6718 d 20:45 ago) @ Helmut Posting: # 1592 Views: 7,032 |
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Dear HS, Thanks  so for parallel design the total CV is 100*(sqrt(MSE)) from the ANOVA table. For a crossover design CV is obtained by using these formulaes from your post what is this MSs in this formula?. Regards Matz |
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mathews ● 2008-02-14 13:10 (6711 d 14:24 ago) @ Helmut Posting: # 1612 Views: 6,978 |
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Dear HS, One more doubt. In the paper S-C Chow and H Wang On Sample Size Calculation in Bioequivalence Trials J Pharmacokin Pharmacodyn 28/2, 2001 they are given sample sizes for parallel design using logtransformed data in Table1. In that table what is the sigma% represents?..Is it the total CV? So if I know the Cmax or AUC value (mean ± s.d). Then is it correct if I calculate the total CV as (s.d/mean)*100.? Is it correct ?. regards Matz. |
Ing. Helmut Schütz