balakotu
★    

India,
2015-09-24 13:55
(3920 d 09:43 ago)

Posting: # 15466
Views: 9,457
 

 Power Calculation for Replicate study designs [Power / Sample Size]

Dear all,

How to calculate power in Partial/full replicate BE studies by using SAS Program.

Regards,
Kotu
d_labes
★★★

Berlin, Germany,
2015-09-24 16:38
(3920 d 07:01 ago)

(edited on 2015-09-24 17:22)
@ balakotu
Posting: # 15467
Views: 7,650
 

 Power Calculation for Replicate study designs with SAS

Dear Kotu,

❝ How to calculate power in Partial/full replicate BE studies by using SAS Program.


We (both) had this question already in 2012 discussed w.r.t. to sample size estimation. Since sample size is based on power the former answer is still valid:

No out of the box solution in SAS :no: I'm aware of. Even not for a conventional 2x2 crossover.


But the add-on package PowerTOST for the statistical language R (free, open source) is much more mature at present time and contains suitable functions for power calculations for replicate designs for ABE decision as well as for scaled ABE decision.

BTW: Do us the favour and post in the appropriate category. There is one named Power / Sample size.


Edit: Category changed ! [Ohlbe]

Regards,

Detlew
Helmut
★★★
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Homepage
Vienna, Austria,
2015-09-25 16:41
(3919 d 06:57 ago)

@ balakotu
Posting: # 15468
Views: 7,457
 

 Beware of the partial replicate

Hi Kotu,

❝ How to calculate power in Partial/full replicate BE studies by using SAS Program.


Why are you interested in (post hoc?) power? If you want to plan a new study (sample size) beware of the partial replicate design. Shit already happened to yourself. Forgotten this one? Either run a fully replicated 3-period (TRT|RTR) or modify the FDA's code to FA0(1).


I concur with Detlew's wish. 50% of your posts were in the wrong category. Is it really that difficult?

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