Bioequivalence and Bioavailability Forum

Subject	Author	Posted	Rep.	last R.	Views
C tau C tau? C tau? Ctau = estimated Cmin? C tau	saimsc007	2012-06-29 10:58	4	2012-06-29 12:14	7,685
Area outside curve Area outside curve Area outside curve AAC AAC AAC AAC AUEC (Phoenix/WinNonlin Model 220) AUEC (Phoenix/WinNonlin Model 220) AUEC (Phoenix/WinNonlin Model 220)	sandipmumbai	2012-05-22 15:00	9	2012-06-28 23:29	8,878
AUCreftmax US, Canada only Canadian variation Canadian variation Canadian variation Canadian variation AUCreftmax	neethu	2010-08-27 08:59	6	2012-06-28 20:29	10,487
Mesalamine PK Metric for BE Evaluation Mesalamine PK Metric for BE Evaluation	hiren379	2012-06-27 12:34	1	2012-06-28 11:42	5,156
which time points to use for calculation of kel which time points to use for calculation of kel which time points to use for calculation of kel which time points to use for calculation of kel which time points to use for calculation of kel which time points to use for calculation of kel Wetware required Geometric, arithmetic, median ... ? Geometric, arithmetic, median ... ? Geometric, arithmetic, median ... ? Geometric, arithmetic, median ... ? Wetware required Wetware required Wetware required Wetware required Wetware required Fit individuals; ignore BQLs	Samir Malhotra	2012-06-12 10:59	16	2012-06-13 18:33	13,818
Kel Determination Kel Determination Kel Determination	jag009	2012-06-01 15:40	2	2012-06-05 18:44	4,745
actual time AUC72 actual time AUC72 actual times and AUC72 actual times and AUC72 WNL/PHX: pAUC72 (=hidden intra-/extrapolation) WNL/PHX: pAUC72 (=hidden intra-/extrapolation) WNL/PHX: pAUC72 (=hidden intra-/extrapolation) WNL/PHX: pAUC72 (=hidden intra-/extrapolation) WNL/PHX: pAUC72 (=hidden intra-/extrapolation) WNL/PHX: pAUC72 (=hidden intra-/extrapolation) pAUC72 or pAUC72+x actual time for INPUT, nominal for the summarisation/report actual time for INPUT, nominal for the summarisation/report actual time for INPUT, nominal for the summarisation/report Fishy? ... don't think so ... don't think so AUCall and that all - Fishy? Genau Detlew!	sciguy	2012-03-23 04:23	18	2012-04-17 15:20	14,774
Determining Elimination Constant (Kel) Ci > Ci-1 (excluding data points) Ci > Ci-1 (excluding data points) Unreliable AUCt Ci > Ci-1 (excluding data points)	jag009	2012-03-15 19:05	4	2012-03-29 16:57	7,918
SD’s Cτ predictive of MD BE?	Helmut	2012-01-24 16:45	0		2,612
AUC truncation in Modified release formulations AUC truncation for MR: depends… AUC truncation in Modified release formulations	rana	2012-01-05 14:30	2	2012-01-09 19:29	4,704
AUC(0-t): how to treat BLQ values? AUC(0-tlast) or AUC(0-72h)? AUC(0-72): estimate? OT - Non-existence of conc=0 OT - Non-existence of conc=0 Off topic - Homeopathy AUC(0-72): estimate?	Oiinkie	2011-11-23 14:58	6	2011-12-05 13:25	18,016
Steady state PK calculation Steady state PK calculation Steady state PK calculation Steady state NCA (WinNonlin)	ratnakar1811	2011-10-03 10:14	3	2011-10-04 11:59	7,395
Cmin (story continued) Cmin (story continued) Cmin (story continued) Cmin (story continued) Cmin (cave: lengthy post) Cmin (cave: lengthy post) Cmin no more? perspective from the PD world perspective from the PD world	Helmut	2011-06-22 17:03	8	2011-09-20 08:20	10,356
secondary parameters secondary metrics	Cmax	2011-07-03 09:08	1	2011-07-03 08:57	4,687
Clast greater than 20 % LLOQ value Clast <LLOQ	ramesh_7779	2011-03-26 10:05	1	2011-03-26 14:14	5,075