Bioequivalence and Bioavailability Forum

Subject	Author	Posted	Rep.	last R.	Views
Difference between Cminss and Ctauss? Difference between Cminss and Ctauss? Difference between Cminss and Ctauss? Difference between Cminss and Ctauss?	tekwani.sunil	2014-12-03 07:10	3	2014-12-04 13:21	7,253
Ctau at steady state calculation Estimated Cτ, if possible	RK	2014-07-03 11:37	1	2014-07-03 22:19	6,676
Regarding the Cτ,ss (Ctau at steady state) calculation What’s stated in the protocol? What’s stated in the protocol? Avoid ambiguities…	murthynaidu	2014-06-20 14:46	3	2014-06-20 14:17	6,707
how to get study state Cmax how to get study state Cmax “study state conditions”? I beg your pardon… I beg your pardon…	DrBABU	2014-05-13 10:35	4	2014-05-14 14:28	6,870
Calculation of AUCt Calculation of AUCt, AUCall, AUCinf... Calculation of AUCt, AUCall, AUCinf... Calculation of AUCt, AUCall, AUCinf... Calculation of AUCt, AUCall, AUCinf... Calculation of AUCt, AUCall, AUCinf... Calculation of AUCt, AUCall, AUCinf... Errors happen Errors happen Calculation of AUCt, AUCall, AUCinf... Calculation of AUCt, AUCall, AUCinf... References	yckim	2007-11-27 02:46	11	2014-03-20 10:03	32,215
Actual time for PK analysis estimated AUC72 estimated AUC72 estimated AUC72 estimated AUC72 estimated AUC72 estimated AUC72 estimated AUC72 estimated AUC72 estimated AUC72 estimated AUC72	ratnakar1811	2013-10-07 08:07	10	2013-10-17 07:34	12,983
Urine concentration data analysis Cumulative amount	RK	2013-08-29 14:27	1	2013-08-29 12:52	4,707
Russian Guidance – PK Data assay Plateau-time etc. Russian Guidance – PK Data assay Russian Guidance – PK Data assay t75% t75% t75% t75% (reporting only?) Partial AUC? Partial AUC? Partial AUC?	Karthikeyan	2013-08-27 13:54	10	2013-08-29 12:04	11,202
Failing BE study due to AUCinf AUC∞ = lousy metric AUC∞ = lousy metric AUC∞ = lousy metric AUC∞ = lousy metric AUC∞ = lousy metric Failing BE study due to AUCinf Failing BE study due to AUCinf BS BS	jag009	2013-06-19 17:44	9	2013-06-20 18:35	9,177
handling of missing data Lin-up/log-down trapezoidal avoids most trouble Lin-up/log-down trapezoidal avoids most trouble Multiple peaks: fallback to linear trapezoidal Multiple peaks: fallback to linear trapezoidal No interpolation No interpolation Spaghetti & other pasta Spaghetti & other pasta Spaghetti & other pasta Spaghetti & other pasta Spaghetti & other pasta Spaghetti & other pasta No interpolation Different algos! Different algos! Calculate what? Lin-up/log-down trapezoidal example Lin-up/log-down trapezoidal example handling of missing data Sorry Sorry Uncertain time point	gracehung	2013-05-20 07:35	22	2013-06-03 16:11	22,479
Long t½ drugs Long t½ drugs Long t½ drugs	jag009	2012-12-05 16:04	2	2012-12-05 21:04	6,261
Difference between Cminss and Ctrough Difference between Cminss and Ctrough EMA’s odd terminology…	rana	2012-11-23 14:49	2	2012-11-23 14:15	19,353
Adderall XR: pAUCs Adderall XR: pAUCs Guidance Sep 2012 Guidance Sep 2012	Helmut	2012-10-01 23:50	3	2012-10-02 14:44	5,947
Cmin calculation steady state Cmin calculation steady state Cmin calculation steady state Cmin - search, search, search and once more: search	VG	2012-07-30 07:02	3	2012-07-31 11:33	8,170
Methods for calculation of half lives Methods for calculation of half lives Methods for calculation of half lives Minimum AIC?! G (Kinetica) = R²adj (WinNonlin) Methods for calculation of half lives MAIC and beyond... TTT method TTT method TTT method TTT method TTT method TTT method TTT method TTT method TTT method Eyeball-PK Eyeball-PK Eyeball-PK Eyeball-PK	d_labes	2008-02-01 14:58	19	2012-07-11 14:24	32,972