Bioequivalence and Bioavailability Forum

Subject	Author	Posted	Rep.	last R.	Views
two-stage design power 90% second stage two-stage design power 90% second stage two-stage design power 90% second stage two-stage design power 90% second stage two-stage design power 90% in sample size adaption two-stage design power 90% in sample size adaption two-stage design power 90% in sample size adaption two-stage design power 90% in sample size adaption Are simulations sufficient? …lenghty post! adjusted alpha = 0.045 adjusted alpha = 0.038 adjusted alpha by sims? Yeah but, no but, yeah but, no but… Yeah but, no but ... Yeah but, no but ...	Yvonne	2012-08-02 09:50	14	2012-08-07 13:14	16,361
Sequential designs, draft FDA guidance Loteprednol What the heck? some unofficial opinion with this regard in Europe Great! Great! Potvin & Montague not acceptable at all?! Powerless Potvin & Montague? Example w.o. intermediate power Example w.o. intermediate power Sims w.o. intermediate power Potvin & Montague not acceptable at all?! Sims?	ElMaestro	2012-07-03 18:33	11	2012-07-26 14:20	23,851
Adaptive BE: concepts Adaptive BE: concepts Adaptive BE: concepts	martin	2012-07-11 20:31	2	2012-07-12 11:36	4,560
2-Stage design Sequential design, maximum sample size in stage 2 Sequential design, maximum sample size in stage 2 Well roared, lion	balakotu	2012-06-21 08:28	3	2012-06-22 06:45	7,462
Two-stage design approach Two-stage design approach	balakotu	2012-06-20 07:18	1	2012-06-20 05:34	4,866
Potvin C or B? Belive in Potvin C? Potvin C or B? Potvin C or B? Potvin C or B? Potvin C or B?	Helmut	2012-06-02 18:54	5	2012-06-07 16:28	13,163
2-stage design - power evaluation No opinions out there? Opinion yes, answer no Decision scheme without (?) power check Decision scheme without (?) power check Decision scheme 'without' power check Decision scheme 'without' power check Numerical example Numerical example Potvin C with unsymmetrical alphas Potvin B, C, or D? Two-stage (classical Pocock) and the FDA Weirdo paper Weirdo paper Weirdo paper	d_labes	2011-10-12 11:10	14	2011-12-01 06:16	20,911
Equations for residual sigmas When it comes to QR factorisation Potentially solved it	ElMaestro	2011-11-18 08:11	2	2011-11-20 17:54	5,716
Two-Stage Sequential Designs Two-Stage Sequential Designs Two-Stage Sequential Designs EMA: Two-Stage Sequential Designs EMA: Two-Stage Sequential Designs EMA: Two-Stage Sequential Designs EMA: Two-Stage Sequential Designs PAR? PAR not yet PAR not yet PAR not yet Potvin C not acceptable! PAR not yet PAR not yet No (?) comment :-(	Helmut	2010-05-20 16:53	14	2011-10-31 14:04	17,872
Two-stage parallel Two-stage parallel Two-stage parallel Interaction needed?	ElMaestro	2011-10-18 04:23	3	2011-10-18 14:32	6,563
two stage design two stage design two stage design two stage design Stage 1 BE two stage design extreme	beman	2011-08-22 15:34	5	2011-08-23 12:51	8,134
EMA: Two-Stage design EMA: Two-Stage design	joyjac	2011-07-05 07:53	1	2011-07-05 17:38	5,046
Potvin method B subtleties Potvin method B subtleties Potvin method B subtleties Potvin method B subtleties Gould Gould Another one ... Oops! Oops! Oops! Oops! Oops! Oops! Simul'ants in my pants Need for speed... Need for speed... Need for speed... Pocock alpha's ElMaestro's brain ElMaestro's brain ElMaestro's brain Numbers Bonus counter-question Speed is the question New paper (method D for PE 0.90) New paper (method D for PE 0.90) New paper (method D for PE 0.90) New paper (method D for PE 0.90) Stopping criterion # futility rule	d_labes	2011-01-31 14:24	28	2011-04-19 13:28	29,410
Two stage replicated design Two stage replicated design Replicate cross-over study done as 2-stage sequential	Priyanka_S	2010-06-24 11:13	2	2010-06-24 12:51	4,779
Two-stage approach (Potvin et al.): model for Stage 2 Two-stage approach (Potvin et al.): model for Stage 2	vezz	2010-06-19 18:35	1	2010-06-20 19:54	5,535