Bioequivalence and Bioavailability Forum

Subject	Author	Posted	Rep.	last R.	Views
An issues I always wondered about - "multiplicity" for power An issues I always wondered about - "multiplicity" for power "multiplicity" for power	Relaxation	2015-11-06 10:25	2	2015-11-06 12:52	9,722
Sample Size for Drugs Interaction studies Sample Size for Drugs Interaction studies Sample Size for Drugs Interaction studies Sample Size for Drugs Interaction studies	Lara	2015-11-03 23:19	3	2015-11-04 17:28	9,228
Sample size with CV more than 100% Why not? Why not? Sample size for HVD's EMA: MR – ABEL for partial AUCs EMA: MR – ABEL for partial AUCs	Jay	2015-11-02 10:47	5	2015-11-02 13:48	10,608
BE studies for Inhalants BE studies for Inhalants BE studies for Inhalants	jag009	2015-10-19 20:32	2	2015-10-23 08:32	8,676
Power Calculation for Replicate study designs Power Calculation for Replicate study designs with SAS Beware of the partial replicate	balakotu	2015-09-24 11:55	2	2015-09-25 12:41	9,453
CV calculation CV calculation CV calculation CV(total) from CV(intra) and CV(inter)	avrahan	2014-09-17 21:40	3	2015-08-27 06:48	11,239
Adjusting for expected dropout-rate Percentage calculation Adjusting for expected dropout-rate - Nitpicking Good point! Good point! Copy paste error Copy paste error PowerTOST <1.2.7? PowerTOST <1.2.7?	Helmut	2015-06-17 12:33	8	2015-08-26 12:41	17,356
post hoc power post hoc power I’m sick of “100.0% power”	VSL	2015-07-01 19:37	2	2015-07-01 23:18	12,098
intra subject variability of Tetrabenazine	Debbie	2015-07-01 13:37	0		4,360
The power of post hoc power The power of post hoc power Ad hoc power Ad hoc power Ad hoc power Hypotheses in non-inferiority trials Hypotheses in non-inferiority trials Hypotheses in non-inferiority trials Hypotheses in non-inferiority trials Hypotheses in non-inferiority trials	The Outlaw Torn	2015-05-13 12:49	9	2015-06-29 06:24	15,665
CV inter-subject Hydroxychloroquine Hydroxychloroquine pooled / total CV Hydroxychloroquine Lousy review process Lousy review process Lousy review process Lousy review process Lousy review process Lousy review process Lousy review process	john john	2015-05-06 12:16	11	2015-05-28 14:10	16,818
Extrapolation CVinter (or CVtotal) from CVintra CVinter (or CVtotal) from CVintra OT: Drug Res OT: Drug Res completely OT completely OT CVinter (or CVtotal) from CVintra CVtotal ≠ CVintra + CVinter CVtotal ≠ CVintra + CVinter CVtotal ≠ CVintra + CVinter CVtotal ≠ CVintra + CVinter CVtotal ≠ CVintra + CVinter CVtotal ≠ CVintra + CVinter CVtotal ≠ CVintra + CVinter	john john	2015-05-13 13:36	14	2015-05-15 13:10	16,057
minimum number of subject in bioequivalence study minimum number of subject in bioequivalence study minimum number of subject in bioequivalence study “Overpowered” studies due to GLs “Overpowered” studies due to GLs “Overpowered” studies due to GLs Scientific Validation for the Sample Size Formula Basic maths Basic maths Reference for CI ⇒ MSE Reference for CI ⇒ MSE Failed study: power <80%! Failed study: power <80%! Reported 99.98%, correct 1.4% Reported 99.98%, correct 1.4% GMR ∉ AR ⇒ power <5% GMR ∉ AR ⇒ power <5%	khaoula	2014-09-27 11:14	16	2015-02-24 16:34	22,014
Different strengths – different ISV? Different strengths – different ISV? Different strengths – different ISV? Different strengths – thanks for advice Planning the study based on the previous results Planning the study based on the previous results Conservatism	mittyri	2014-12-21 18:04	6	2015-02-12 12:31	12,017
No of Vonteers requirment No of Vonteers requirment Sample size for scABE FDA (RSABE) vs. EMA (ABEL)	Srinetram	2015-01-08 06:41	3	2015-01-08 12:57	8,424