Bioequivalence and Bioavailability Forum

Subject	Author	Posted	Rep.	last R.	Views
Point Estimate consideration in sample size estimate Point Estimate consideration in sample size estimate Point Estimate consideration in sample size estimate BE = CI within acceptance range (PE is irrelevant) BE = CI within acceptance range (PE is irrelevant) BE = CI within acceptance range (PE is irrelevant) BE = CI within acceptance range (PE is irrelevant)	kimhuang	2025-10-09 07:21	6	2025-10-16 09:37	3,462
Reverse Engineering → Back calculate the intra CV Why not? Why not? degrees of freedom degrees of freedom of partial replicate 2x3x3 degrees of freedom of partial replicate 2x3x3 degrees of freedom of partial replicate 2x3x3	jag009	2013-05-03 16:45	6	2025-07-14 09:59	10,367
Significance Significance Significance Quality vs. Clinical Sample size? Sample size? Sample size? Sample size, ratio, CV ↔ power Sample size, ratio, CV ↔ power Sample size, ratio, CV ↔ power TOST != treatment effect Sample size, ratio, CV ↔ power Not vice versa Not vice versa? Not vice versa? Sample size calculation using Marzo and Balant method Marzo / Balant formula Marzo / Balant formula Marzo / Balant formula Marzo / Balant formula for parallel groups	The Outlaw Torn	2012-11-20 07:56	19	2025-02-25 06:12	23,060
how to construct confidence interval for un-transformed metric? how to construct confidence interval for un-transformed metric? how to construct confidence interval for un-transformed metric? Fieller’s confidence interval Fieller’s confidence interval Fieller’s confidence interval Rescue approaching – PowerTOST Rescue approaching – PowerTOST Why not base 🇷? Why not base 🇷?	lizhao	2016-02-17 19:01	9	2025-02-15 20:42	17,007
software for calculating sample size for replicate bioequivalence studies 🇷 package PowerTOST	gsrao2022	2024-09-24 17:21	1	2024-09-24 19:33	4,123
Sequential Sample Size and Power Estimate in R IUT IUT power is analytically accessible Power<50% Power<50% Power<50%	xpresso	2023-09-19 13:40	6	2024-03-01 23:02	8,550
Sample size calculation for NTI molecules PowerTOST: sampleN.NTIDFDA() PowerTOST: sampleN.NTIDFDA() 'CVcap' sampleN.NTIDFDA(), power.NTIDFDA, pa.NTIDFDA are deprecated	narra1813	2019-08-10 09:21	4	2024-02-26 10:54	11,289
Power TOST question Power TOST question Power TOST question Total sample size vs. vector of groups sizes	Achievwin	2024-02-20 19:49	3	2024-02-23 10:06	6,265
sampleN.TOST vs. sampleN.scABEL ABEL is a framework (decision scheme) ABEL is a framework (decision scheme) ABEL vs. ABE ABEL vs. ABE Being able to read does not hurt… Being able to read does not hurt… Being able to read does not hurt… Vet BE Guideline	BEQool	2024-01-29 11:53	8	2024-02-05 16:49	9,770
Go/No-go Decision for Pivotal Study Problematic T/R-ratio… TSD? sample size for TSD is better than for 1SD?	NK	2023-12-27 12:15	3	2024-01-01 19:54	6,230
FDA: PD BE study FDA: PD BE study	balakotu	2023-07-12 04:24	1	2023-07-13 08:45	5,172
Sample size estimation for parallel design with more than 2 treatments Sample size estimation for parallel design with more than 2 treatments >2 treatments, multiplicity or not >2 treatments, multiplicity or not	BEQool	2023-05-24 21:05	3	2023-05-29 10:41	6,311
Sample Size Benefits of Replicate Design with ABE Sample Size Benefits of Replicate Design with ABE Dropouts less problematic	Sereng	2023-05-24 15:41	2	2023-05-25 16:27	5,914
R Validation R Validation R Validation R Validation	Imph	2023-05-14 13:48	3	2023-05-15 13:42	5,658
Sample size estimation for parallel design Parallel designs (total variance) Parallel designs (total variance) CV-intra # 60% CV-inter total (pooled) variance: examples total (pooled) variance: examples total (pooled) variance: examples Higher-Order Crossovers Higher-Order Crossovers total (pooled) variance: examples total (pooled) variance: examples total (pooled) variance: examples total (pooled) variance: examples total (pooled) variance: examples total (pooled) variance: examples Sample size estimation for parallel design	Nav Coelho	2007-07-20 16:14	15	2023-05-04 08:17	35,892