SPSS code for standard crossover [Software]
Dear all,
As promised , below you'll find an SPSS code to analyze a standard 2x2x2 crossover BE study. In your data sheet, name your columns something like subject, period, sequence, treatment, Cmax, AUCt, AUCinf..., and fill in your data. In the treatment/formulation column test product should be coded 1 and reference 2; sequence 1=TR and 2=RT (as opposed to bear). ln Cmax can be automatically computed (if you'd like to do this in SPSS, column lnCmax will be added to your data sheet) by
NCA is not included, so you have to compute your PK parameters first with e.g. bear, pksolver for M$ Excel, SAS or any other...
Include
Hope this may be useful to the very few that use SPSS in the BE/PK world
As promised , below you'll find an SPSS code to analyze a standard 2x2x2 crossover BE study. In your data sheet, name your columns something like subject, period, sequence, treatment, Cmax, AUCt, AUCinf..., and fill in your data. In the treatment/formulation column test product should be coded 1 and reference 2; sequence 1=TR and 2=RT (as opposed to bear). ln Cmax can be automatically computed (if you'd like to do this in SPSS, column lnCmax will be added to your data sheet) by
COMPUTE lnCmax=LN(Cmax).
EXECUTE.
NCA is not included, so you have to compute your PK parameters first with e.g. bear, pksolver for M$ Excel, SAS or any other...
GLM
lnCmax BY period sequence treatment subject
/CONTRAST(treatment)=Simple
/METHOD=SSTYPE(3)
/INTERCEPT=INCLUDE
/CRITERIA=ALPHA(.1)
/PRINT=DESCRIPTIVE <--optional
/DESIGN= subject within sequence period treatment sequence.
Include
/RANDOM=subject
to set subject as random factor (not recommended by the guideline). You may back-transform the results to obtain GMR PE and 90% CI. CVintra is obtained from the MSE, obviously. I have "validated" my SPSS results with SAS and bear.Hope this may be useful to the very few that use SPSS in the BE/PK world
—
Regards,
Oiinkie
Regards,
Oiinkie
Complete thread:
- SPSS code for standard crossoverOiinkie 2013-02-07 18:17 [Software]