Bioequivalence and Bioavailability Forum

What a mess! [Software]

posted by Helmut  – Vienna, Austria, 2013-01-09 16:18 (4553 d 01:00 ago) – Posting: # 9802
Views: 13,645

Dear Detlew,

❝ ❝ ❝ … thus we can't empirical test it via simulations.

❝ ❝ Not sure what you mean here.

❝

❝ I meant that simulations with θ_L ≤ 90% CI ≤ θ_U do not give substantial different results compared to θ_L < 90% CI < θ_U. Thus we can't choose that alternative which is closer to the analytical power calculation results…

Ah, now I understand! Theoretically (!) it would be possible if one goes with the R-package Rmpfr allowing for high numeric precision or Maxima and run a zillion of sim’s. Would need a supercomputer in the backyard.

❝ … (of course via PowerTOST ).

What else?
In my future sim’s of alpha (rounded CI) I will go for a ratio 0.80 instead of 1.25 since all three algos we have discussed give the same results there. Nevertheless, more studies than the 5% expected will pass making a significant result difficult to interpret.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Rounding Helmut 2013-01-01 16:51 [Software] 
  • Rounding d_labes 2013-01-02 12:51
    • Rounding Helmut 2013-01-04 17:35
      • Rounding d_labes 2013-01-05 19:25
        • Rounding Helmut 2013-01-05 20:13
          • Sim’s are sim’s are sim’s d_labes 2013-01-05 20:57
        • Another vicious circle Helmut 2013-01-06 02:21
          • Where all these numbers came from? d_labes 2013-01-07 15:52
            • Flaw in the GL? Helmut 2013-01-07 17:29
              • Flaw in the GL? d_labes 2013-01-08 11:44
                • What a mess! Helmut 2013-01-08 19:08
                  • What a mess! d_labes 2013-01-09 10:33
                    • What a mess!Helmut 2013-01-09 15:18
  • Rounding ElMaestro 2013-01-02 16:12
    • Abandon rounding Helmut 2013-01-02 17:04
  • Rounding yjlee168 2013-01-05 23:15
    • Rounding Helmut 2013-01-06 03:29
    • Rounding Helmut 2013-01-06 15:34
      • Rounding yjlee168 2013-01-06 23:38