Bioequivalence and Bioavailability Forum

What a mess! [Software]

posted by d_labes  – Berlin, Germany, 2013-01-09 11:33 (4501 d 19:44 ago) – Posting: # 9801
Views: 12,416

Dear Helmut,

❝ In my home-brew BE software I didn’t round at all, but tested for θ_L ≤ 90% CI ≤ θ_U.

Me too. From our sponsors perspective it's the better choice and if rounding comes into play it looks much better . In that sense the R rounding is also a good choice.

❝ ❝ … thus we can't empirical test it via simulations.

❝ Not sure what you mean here.

I meant that simulations with θ_L ≤ 90% CI ≤ θ_U do not give substantial different results compared to θ_L < 90% CI < θ_U. Thus we can't choose that alternative which is closer to the analytical power calculation results (of course via PowerTOST ).

Complete thread:

• Rounding Helmut 2013-01-01 16:51 [Software] 
  • Rounding d_labes 2013-01-02 12:51
    • Rounding Helmut 2013-01-04 17:35
      • Rounding d_labes 2013-01-05 19:25
        • Rounding Helmut 2013-01-05 20:13
          • Sim’s are sim’s are sim’s d_labes 2013-01-05 20:57
        • Another vicious circle Helmut 2013-01-06 02:21
          • Where all these numbers came from? d_labes 2013-01-07 15:52
            • Flaw in the GL? Helmut 2013-01-07 17:29
              • Flaw in the GL? d_labes 2013-01-08 11:44
                • What a mess! Helmut 2013-01-08 19:08
                  • What a mess!d_labes 2013-01-09 10:33
                    • What a mess! Helmut 2013-01-09 15:18
  • Rounding ElMaestro 2013-01-02 16:12
    • Abandon rounding Helmut 2013-01-02 17:04
  • Rounding yjlee168 2013-01-05 23:15
    • Rounding Helmut 2013-01-06 03:29
    • Rounding Helmut 2013-01-06 15:34
      • Rounding yjlee168 2013-01-06 23:38