Bioequivalence and Bioavailability Forum

Rounding [Software]

posted by Helmut  – Vienna, Austria, 2013-01-05 21:13 (4505 d 09:27 ago) – Posting: # 9788
Views: 12,651

Dear Detlew!

❝ ❝ ... In the meantime I finished my balanced cross-over sim’s. n 12–60, CV 6–100%. With my grid I have 306·10⁶ sim’s each. With rounding I got 24 (7.84%) empiric alphas significantly >0.05; without 11 (3.59%).

❝

❝ How do you interpret the un-rounded results?

The jury is out. I ran two sim’s with identical seeds to compare the results. Nice intermediate result files (33.1MB unrounded, 14MB rounded). Have to find a clever way to filter for the suspects.

❝ Empirical evidence of an Alpha inflation of TOST ?

❝ Hopefully not.

Don’t think so. On the other hand it puts occasional significant alphas I got in Methods B/C/D into perspective.

Sim’s are sim’s are sim’s.

It’s like with lab values. The more your physician requests, the more “*” you’ll get – though not being ill.

❝ Here I have another one:

❝ round(c(1.2500499999999999, 1.250049999999999999), 4)

❝ [1] 1.2500 1.2501

You are a nasty person.

❝ More trouble spots can be found in "The R inferno".

❝ Should be a must-read for all R-users.

Wow!

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Rounding Helmut 2013-01-01 16:51 [Software] 
  • Rounding d_labes 2013-01-02 12:51
    • Rounding Helmut 2013-01-04 17:35
      • Rounding d_labes 2013-01-05 19:25
        • RoundingHelmut 2013-01-05 20:13
          • Sim’s are sim’s are sim’s d_labes 2013-01-05 20:57
        • Another vicious circle Helmut 2013-01-06 02:21
          • Where all these numbers came from? d_labes 2013-01-07 15:52
            • Flaw in the GL? Helmut 2013-01-07 17:29
              • Flaw in the GL? d_labes 2013-01-08 11:44
                • What a mess! Helmut 2013-01-08 19:08
                  • What a mess! d_labes 2013-01-09 10:33
                    • What a mess! Helmut 2013-01-09 15:18
  • Rounding ElMaestro 2013-01-02 16:12
    • Abandon rounding Helmut 2013-01-02 17:04
  • Rounding yjlee168 2013-01-05 23:15
    • Rounding Helmut 2013-01-06 03:29
    • Rounding Helmut 2013-01-06 15:34
      • Rounding yjlee168 2013-01-06 23:38