Bioequivalence and Bioavailability Forum

I’ll try [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2012-12-29 16:42 (4563 d 18:03 ago) – Posting: # 9765
Views: 8,838

Hi ElMaestro,

❝ Are we talking one-stage or two-stage designs?

One stage (fixed sample 2,2,2 cross-over). Duno what to say else that I did in my original post. Is it true or not that α might be inflated in imbalanced studies? I’m not talking about nominal α (which is ≤0.05) but the one we can expect using the usual methods… If this is just a rumor, fine. If not, how large an inflation can we expect?

❝ Imbalance has not been studied for two-stage designs.

Yep. BTW

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Helmut Schütz


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Complete thread:

• Imbalanced Xovers: α-inflation? Helmut 2012-12-27 17:21 [General Sta­tis­tics] 
  • Imbalanced Xovers: α-inflation? ElMaestro 2012-12-28 09:30
    • Imbalanced Xovers: α-inflation? Helmut 2012-12-28 14:37
      • please explain ElMaestro 2012-12-29 08:44
        • I’ll tryHelmut 2012-12-29 15:42
  • Imbalanced Xovers: α-inflation? d_labes 2012-12-31 13:50
  • One Mio sims of 2x2x2 in R in under 1 sec d_labes 2013-01-09 15:23
    • Wow! Helmut 2013-01-09 16:10
      • Unbalanced d_labes 2013-01-09 16:56
        • α-inflation ≈ urban myth Helmut 2013-01-09 18:07
          • Beer d_labes 2013-01-10 11:07
            • Beer Helmut 2013-01-10 13:45